Dr. Jeff Wrana and team follow a gut feeling and discover a new type of stem cell
Wednesday, April 24, 2019: A new type of cell has been discovered in the intestinal lining, named the “revival stem cell”. Dr. Wrana, who is a Senior Scientist at the Lunenfeld-Tanenbaum Research Institute, and a team of researchers have found the revival stem cell plays a central role in the regenerative process in the intestine.
Implication of a placental protein in protection against development of insulin resistance in early life
Tuesday, April 02, 2019: A placental protein called placental 11 Β-hydroxysteroid dehydrogenase 2 (11Β-HSD2) may protect against the development of T2DM in early life
Non-invasive detection of certain cancers on the horizon
Wednesday, November 14, 2018: The realization of the promising field of “liquid biopsy” for cancer detection moved closer this week, with a fascinating new paper published in Nature that measures cancer risk by detecting a type of DNA modification called methylation in circulating DNA in blood
New Discovery - A built-in killer switch eliminates dividing cells from lab-grown transplant tissue to improve patient safety
Wednesday, November 14, 2018: Cells hold great potential as medicine but they can’t be trusted in their current form. “Cells that can divide are dangerous by their nature,”...
Dr. Jeff Wrana Awarded Major Prize for Contributions to Cancer Research
Tuesday, September 18, 2018: Dr. Jeff Wrana, Senior Investigator at the Lunenfeld-Tanenbaum Research Institute, has been awarded the 2018 McLaughlin Medal by the Royal Society of Canada (RSC), recognizing his pivotal contributions to our understanding of biology, human diseases, and its treatment. The RSC also recognized his leadership in the promotion of “Canadian science through collaborative research facilities and international impact.” Dr. Wrana’s vast accomplishments include delineation of the Transforming Growth Factor beta signal transduction system which plays a key role in cancer development and spread.
LINE dancing - a new and essential role for repetitive DNA in embryonic development
Thursday, June 21, 2018: Biologists have long known about segments of repeated sequences of DNA – together such elements comprise almost half of our genomes (and those of other species)... A research team led by Dr. Miguel Ramalho-Santos has now uncovered an important and novel role for the most common of these repetitive elements, called LINE1, which accounts for a full 24% of the human genome.
Sins of the Father - New Research Explores How an RNA-Binding Protein Prevents Paternally-Mediated Epigenetic Sterility
Thursday, August 24, 2017: C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility. Until the past 15 years or so, it was believed that DNA was the sole blueprint of life. Scientists and laypeople alike supposed that all phenotypes arose only from specific sequences of nucleotides in DNA.
Unravelling the Web of Protein Interactions - Introducing ProHits-viz
Wednesday, July 19, 2017: The field of biochemistry – understanding the chemistry of life – began with reductionism. This reductionist approach provided a linear understanding of protein interaction: that one protein performs an action, which is then directly transmitted to another protein. However, thanks to the work of scientists like the late Dr. Tony Pawson, researchers in the fields of biochemistry and cell biology began to realise that proteins do not work in this merely linear fashion. Instead, they are often part of molecular machines comprised of many proteins, often with transient and variegated interactions.
Getting to the Core of the Problem - New Research Delves into the Role of MOB1 in the Hippo Signalling Pathway
Friday, July 07, 2017: Understanding the complex cellular pathways involved in cancer is a critical aspect in understanding the disease itself. Moreover, studying these pathways may also provide insights for development of new treatments targeted at disrupting aspects of pathways that are disrupted in cancer. Two complementary, recent publications from research teams at the LTRI