Sins of the Father - New Research Explores How an RNA-Binding Protein Prevents Paternally-Mediated Epigenetic Sterility
Thursday, August 24, 2017: C. elegans SUP-46, an HNRNPM family RNA-binding protein that prevents paternally-mediated epigenetic sterility. Until the past 15 years or so, it was believed that DNA was the sole blueprint of life. Scientists and laypeople alike supposed that all phenotypes arose only from specific sequences of nucleotides in DNA.
Unravelling the Web of Protein Interactions - Introducing ProHits-viz
Wednesday, July 19, 2017: The field of biochemistry – understanding the chemistry of life – began with reductionism. This reductionist approach provided a linear understanding of protein interaction: that one protein performs an action, which is then directly transmitted to another protein. However, thanks to the work of scientists like the late Dr. Tony Pawson, researchers in the fields of biochemistry and cell biology began to realise that proteins do not work in this merely linear fashion. Instead, they are often part of molecular machines comprised of many proteins, often with transient and variegated interactions.
Getting to the Core of the Problem - New Research Delves into the Role of MOB1 in the Hippo Signalling Pathway
Friday, July 07, 2017: Understanding the complex cellular pathways involved in cancer is a critical aspect in understanding the disease itself. Moreover, studying these pathways may also provide insights for development of new treatments targeted at disrupting aspects of pathways that are disrupted in cancer. Two complementary, recent publications from research teams at the LTRI
Lending Regeneration a Helping Hand - New research suggests TGF-B allows cultured chondrocytes to redifferentiate
Friday, June 23, 2017: According to the Arthritis Society, over three million Canadian suffer from osteoarthritis. This disease affects the cartilage of joints between bones, causing it to break down and resulting in pain, stiffness, and swelling in affected joints, as well as a reduction in the quality of life of sufferers. Moreover, this disease is not only progressive and debilitating, but also currently incurable. While treatments aimed at alleviating symptoms exist, there is a dire need for therapies that can regenerate lost cartilage.
From Jellyfish to Cancer Cells - Why Fluorescent Proteins Are Crucial to Biomedical Research
Monday, June 12, 2017: Brightly glowing cells frequently grace the covers of scientific journals in an array of vivid colours. While often beautiful, their significance to scientific research may not be immediately evident. Put more simply: why do our experiments glow, and why is this important? Many of us have seen images like those of white lab mice that glow green under UV light and have wondered, perhaps, what value exists in such a trait...
Friends, Foes, and Everything In Between - Why Bacteria Get a Bad Rap
Friday, March 31, 2017: Humans have a fraught relationship with bacteria. Advertising for antibacterial soaps, disinfectants, and air purifiers would have us believe that all bacteria are enemies to be eliminated. But contradictions to this message pour in from the flourishing market of probiotics, insisting that our health depends on consuming as many bacteria as we can.
Undermining Malignancy – The next step in understanding Plk4-mediated cancer cell metastasis and invasion
Monday, March 20, 2017: What makes a tumour malignant (and therefore cancerous), and not merely benign? This is a crucial question, given that while benign growths can pose health risks, the malignancy of cancerous growths makes them far more dangerous than their benign counterparts.
New insights into predicting the most aggressive forms of prostate cancer
Tuesday, March 14, 2017: Most prostate cancer (PCa) is diagnosed through a blood test, serum PSA testing. The well appreciated down-side of PSA testing is the diagnosis of a considerable proportion of indolent cancers that are highly unlikely to progress to clinically significant, lethal disease. Our limited ability to accurately identify men destined to suffer and die from the disease from the majority of indolent cases is a major concern and contributes to the dilemma regarding PCa screening and its genetic testing. - This paper is dedicated to the memory of our long time colleague and dear friend, Dr. Hilmi Ozcelik.
Dr. Daniel Drucker honoured with two awards recognizing his outstanding contributions to fundamental and clinical studies of GLP-1 and GLP-2
Tuesday, March 14, 2017: In previous years, Dr. Drucker has garnered worldwide recognition for his work, including having been awarded the Banting Medal for Scientific Achievement, appointed an Officer of the Order of Canada and elected as a fellow to the Royal Society. He is now the 2017 recipient of the Rolf Luft Award, and shares in the 2017 Harrington Prize for Innovation in Medicine with Drs. Habener and Holst.
Old molecule, new use - researchers show how heparin can help prevent preeclampsia
Thursday, February 02, 2017: Low Molecular Weight Heparin Improves Endothelial Function in Pregnant Women at High Risk of Preeclampsia
Disarming Dysentery - How Pathogenic Bacteria Subvert Cellular Defense Mechanisms
Monday, January 23, 2017: According to the World Health Organization (WHO), diarrhea persists as one of the leading causes of childhood mortality. A 2009 WHO report declared "nearly nine million children under five years of age die each year… [and] diarrhea is second only to pneumonia as the cause of these deaths.” …
How stigma can kill - LTRI researchers argue that destigmatization is a key strategy to fighting opioid overdose
Friday, January 20, 2017: Drugs, especially opioid painkillers, are an essential tool in modern medicine. However, drug overdose is a significant cause of death worldwide, with the World Health Organization estimating that opioid overdose alone causes 69,000 deaths a year (as of 2014). ...
Worms and Flies - How These Not-So-Distant Cousins Help Us Understand Ourselves
Thursday, January 12, 2017: “Wait, you study bugs? I thought you said you were a cancer researcher!” It’s something that scientists who work with model organisms hear a little more often than we’d like. But for good reason—at first glance, it might be difficult to see why ...
TCP Awarded Exceptional Grant to Extend its Role as a National Science Facility
Monday, January 09, 2017: The Centre for Phenogenomics (TCP), a world class facility that develops mouse models of human diseases, has been awarded a grant of $15.41 million over the next 5 years from the Canada Foundation for Innovation. ...
A new theory for autism that may underpin up to a third of cases given support from a new mouse model
Thursday, December 15, 2016: Teams led by Professors Benjamin Blencowe, of the University of Toronto’s Donnelly Centre, and Sabine Cordes, of Sinai Health’s Lunenfeld-Tanenbaum Research Institute, induced autistic-like behaviour in mice by lowering the levels of a protein called nSR100 (also known as SRRM4), which is important for normal brain development ...
Ten questions about how learning and memories work - answered by Dr. Graham Collingridge
Tuesday, December 06, 2016: Memory in computers may get bigger and better all the time, but the same can't be said for the human computer. Memory in people is finite, fickle and perhaps fleeting. For 10 questions on human memory, The Agenda welcomes Dr. Graham Collingridge, a recent winner of The Brain Prize, often referred to as the Nobel of neuroscience
Comprehensive Analysis Reveals How Protein Phosphatases Control Critical Cell Processes Such as Cell Division
Friday, November 25, 2016: Reversible protein phosphorylation occurs with precise regulation, ensuring that a cell responds to its environment with efficiency and speed. ...
Why bad genes aren’t always bad news
Thursday, November 03, 2016: A study paving the way for understanding how some people stay healthy despite having disease-causing mutations
A Big Bang Theory for Pancreatic Cancer
Thursday, October 13, 2016: evidence for pancreatic cancers starting with a virtually simultaneous collection of mutations; in many cancers, mutations in key tumour associated genes act in a sequential manner, ratcheting up the aggressiveness and severity of the tumour over a period of time
Seeing is believing - New molecular structure sheds light on DNA repair
Tuesday, August 09, 2016: thanks to a collaboration between Mount Sinai Hospital’s Lunenfeld-Tanenbaum Research Institute (LTRI), part of Sinai Health System, and The Hospital for Sick Children (SickKids), Toronto scientists have caught a glimpse of the molecules involved in DNA repair
Dr. Sabine Cordes, winner of Lloyd S.D. Fogler, QC, Award of Excellence
Friday, July 29, 2016: Dr. Sabine Cordes, Senior Investigator from the Lunenfeld Tanenbaum Research Institute has recently been named the recipient of the Lloyd S.D. Fogler, QC, Award of Excellence for her work on mood disorders.
Glimpsing the bright future of health research
Tuesday, July 19, 2016: The Summer Student Poster Seminar – the annual end to the 3-month long research program for undergraduate students.
Communicating Science - itʼs in us to give
Wednesday, July 13, 2016: The RTC Career Development Committee recently welcomed Dan Riskin, PhD and co-host of the Daily Planet, to the LTRI for their first in a series of career development lectures and workshops.
The Brain Prize MAKING MEMORIES
Wednesday, June 08, 2016: Graham Collingridge discusses the challenges and pleasures of studying the brain, as well as his recent awarding of the Brain Prize.
More tricks with next-generation DNA sequencing - DNA barcodes gone wild
Friday, April 22, 2016: A team of researchers at Sinai Health System’s Lunenfeld-Tanenbaum Research Institute (LTRI) and University of Toronto’s Donnelly Centre has developed a new technology that can stitch together DNA barcodes inside a cell to simultaneously search amongst millions of protein pairs for protein interactions. The paper will be published today in the journal Molecular Systems Biology.
Early Childhood Development - A Smart Beginning for Economies on the Rise
Thursday, April 14, 2016: Professor Stephen Lye, executive director of U of T’s Fraser Mustard Institute for Human Development, speaking at a recent World Band/UNICEF event. You’re not too late to hear his insights into how experiences during the first 2000 days of life shape early brain development and impact a child's life-long health, economic achievement and social wellbeing. (beginning at the 25-minute mark)
Top international Brain Prize awarded to LTRI researcher
Tuesday, March 01, 2016: Dr. Graham Collingridge, neuroscientist with Lunenfeld-Tanenbaum Research Institute and University of Toronto announced as award recipient - (reprinted from: http://www.mountsinai.on.ca/about_us/news/2016-news/top-brain-prize-awarded#sthash.8j2oxghr.dpuf)
Loose DNA does not sink ships
Monday, February 01, 2016: The cell nucleus contains a highly packaged but addressable array of DNA that must both permit controlled and modulated expression of genes but also be able to maintain integrity of that DNA through precision repair processes - a new study published in Nature Cell Biology, by the research teams of Daniel Durocher and Laurence Pelletier...
Celebrating a key Canadian cancer discovery
Wednesday, December 16, 2015: McGill's Phil Gold describes the discovery of CEA 50 years ago
Flipping the repair switch to edit our genes
Wednesday, December 09, 2015: A new discovery, based on elucidating how cells control DNA repair, may be a key to editing genes directly in the human body as a means to cure or reverse disease.
Old gene’s new tricks shed light on diabetes
Monday, December 07, 2015: Dr. Drucker and his colleagues at the Lunenfeld-Tanenbaum Research Institute (LTRI) have found a surprising connection between a hormone that is produced in the gut and TCF7 – a gene previously only known to work in the immune system - in the development of diabetes.
Drug discovered in Canada now approved in Canada
Friday, December 04, 2015: ...thanks to research led by Dr. Daniel Drucker, Senior Investigator with Lunenfeld-Tanenbaum Research Institute, part of Sinai Health System, a new drug for short bowel syndrome has been approved by Health Canada.
New protein map reveals cell’s long-held secrets
Friday, December 04, 2015: A team of Toronto scientists have zoomed in on an elusive part of the cell to uncover thousands of molecular events that underlie some of the most common human diseases.
New insight into how colon cancer arises
Wednesday, October 21, 2015: In this week's issue of Nature, Dr. Alex Gregorieff and his colleagues from the laboratory of Dr. Jeff Wrana published evidence linking gut repair after damage and progression of colon cancer.