Undermining Malignancy – The next step in understanding Plk4-mediated cancer cell metastasis and invasion
Monday, March 20, 2017: What makes a tumour malignant (and therefore cancerous), and not merely benign? This is a crucial question, given that while benign growths can pose health risks, the malignancy of cancerous growths makes them far more dangerous than their benign counterparts.
New insights into predicting the most aggressive forms of prostate cancer
Tuesday, March 14, 2017: Most prostate cancer (PCa) is diagnosed through a blood test, serum PSA testing. The well appreciated down-side of PSA testing is the diagnosis of a considerable proportion of indolent cancers that are highly unlikely to progress to clinically significant, lethal disease. Our limited ability to accurately identify men destined to suffer and die from the disease from the majority of indolent cases is a major concern and contributes to the dilemma regarding PCa screening and its genetic testing. - This paper is dedicated to the memory of our long time colleague and dear friend, Dr. Hilmi Ozcelik.
Dr. Daniel Drucker honoured with two awards recognizing his outstanding contributions to fundamental and clinical studies of GLP-1 and GLP-2
Tuesday, March 14, 2017: In previous years, Dr. Drucker has garnered worldwide recognition for his work, including having been awarded the Banting Medal for Scientific Achievement, appointed an Officer of the Order of Canada and elected as a fellow to the Royal Society. He is now the 2017 recipient of the Rolf Luft Award, and shares in the 2017 Harrington Prize for Innovation in Medicine with Drs. Habener and Holst.
Old molecule, new use - researchers show how heparin can help prevent preeclampsia
Thursday, February 02, 2017: Low Molecular Weight Heparin Improves Endothelial Function in Pregnant Women at High Risk of Preeclampsia
Disarming Dysentery - How Pathogenic Bacteria Subvert Cellular Defense Mechanisms
Monday, January 23, 2017: According to the World Health Organization (WHO), diarrhea persists as one of the leading causes of childhood mortality. A 2009 WHO report declared “nearly nine million children under five years of age die each year… [and] diarrhea is second only to pneumonia as the cause of these deaths.” ...
How stigma can kill - LTRI researchers argue that destigmatization is a key strategy to fighting opioid overdose
Friday, January 20, 2017: Drugs, especially opioid painkillers, are an essential tool in modern medicine. However, drug overdose is a significant cause of death worldwide, with the World Health Organization estimating that opioid overdose alone causes 69,000 deaths a year (as of 2014). ...
Worms and Flies - How These Not-So-Distant Cousins Help Us Understand Ourselves
Thursday, January 12, 2017: “Wait, you study bugs? I thought you said you were a cancer researcher!” It’s something that scientists who work with model organisms hear a little more often than we’d like. But for good reason—at first glance, it might be difficult to see why ...
TCP Awarded Exceptional Grant to Extend its Role as a National Science Facility
Monday, January 09, 2017: The Centre for Phenogenomics (TCP), a world class facility that develops mouse models of human diseases, has been awarded a grant of $15.41 million over the next 5 years from the Canada Foundation for Innovation. ...
A new theory for autism that may underpin up to a third of cases given support from a new mouse model
Thursday, December 15, 2016: Teams led by Professors Benjamin Blencowe, of the University of Toronto’s Donnelly Centre, and Sabine Cordes, of Sinai Health’s Lunenfeld-Tanenbaum Research Institute, induced autistic-like behaviour in mice by lowering the levels of a protein called nSR100 (also known as SRRM4), which is important for normal brain development ...
Ten questions about how learning and memories work - answered by Dr. Graham Collingridge
Tuesday, December 06, 2016: Memory in computers may get bigger and better all the time, but the same can't be said for the human computer. Memory in people is finite, fickle and perhaps fleeting. For 10 questions on human memory, The Agenda welcomes Dr. Graham Collingridge, a recent winner of The Brain Prize, often referred to as the Nobel of neuroscience …
Comprehensive Analysis Reveals How Protein Phosphatases Control Critical Cell Processes Such as Cell Division
Friday, November 25, 2016: Reversible protein phosphorylation occurs with precise regulation, ensuring that a cell responds to its environment with efficiency and speed. ...
Why bad genes aren’t always bad news
Thursday, November 03, 2016: A study paving the way for understanding how some people stay healthy despite having disease-causing mutations
A Big Bang Theory for Pancreatic Cancer
Thursday, October 13, 2016: evidence for pancreatic cancers starting with a virtually simultaneous collection of mutations; in many cancers, mutations in key tumour associated genes act in a sequential manner, ratcheting up the aggressiveness and severity of the tumour over a period of time
Seeing is believing - New molecular structure sheds light on DNA repair
Tuesday, August 09, 2016: thanks to a collaboration between Mount Sinai Hospital’s Lunenfeld-Tanenbaum Research Institute (LTRI), part of Sinai Health System, and The Hospital for Sick Children (SickKids), Toronto scientists have caught a glimpse of the molecules involved in DNA repair
Dr. Sabine Cordes, winner of Lloyd S.D. Fogler, QC, Award of Excellence
Friday, July 29, 2016: Dr. Sabine Cordes, Senior Investigator from the Lunenfeld Tanenbaum Research Institute has recently been named the recipient of the Lloyd S.D. Fogler, QC, Award of Excellence for her work on mood disorders.
Glimpsing the bright future of health research
Tuesday, July 19, 2016: The Summer Student Poster Seminar – the annual end to the 3-month long research program for undergraduate students.
Communicating Science - itʼs in us to give
Wednesday, July 13, 2016: The RTC Career Development Committee recently welcomed Dan Riskin, PhD and co-host of the Daily Planet, to the LTRI for their first in a series of career development lectures and workshops.
The Brain Prize MAKING MEMORIES
Wednesday, June 08, 2016: Graham Collingridge discusses the challenges and pleasures of studying the brain, as well as his recent awarding of the Brain Prize.
More tricks with next-generation DNA sequencing - DNA barcodes gone wild
Friday, April 22, 2016: A team of researchers at Sinai Health System’s Lunenfeld-Tanenbaum Research Institute (LTRI) and University of Toronto’s Donnelly Centre has developed a new technology that can stitch together DNA barcodes inside a cell to simultaneously search amongst millions of protein pairs for protein interactions. The paper will be published today in the journal Molecular Systems Biology.
Early Childhood Development - A Smart Beginning for Economies on the Rise
Thursday, April 14, 2016: Professor Stephen Lye, executive director of U of T’s Fraser Mustard Institute for Human Development, speaking at a recent World Band/UNICEF event. You’re not too late to hear his insights into how experiences during the first 2000 days of life shape early brain development and impact a child's life-long health, economic achievement and social wellbeing. (beginning at the 25-minute mark)
Top international Brain Prize awarded to LTRI researcher
Tuesday, March 01, 2016: Dr. Graham Collingridge, neuroscientist with Lunenfeld-Tanenbaum Research Institute and University of Toronto announced as award recipient - (reprinted from: http://www.mountsinai.on.ca/about_us/news/2016-news/top-brain-prize-awarded#sthash.8j2oxghr.dpuf)
Loose DNA does not sink ships
Monday, February 01, 2016: The cell nucleus contains a highly packaged but addressable array of DNA that must both permit controlled and modulated expression of genes but also be able to maintain integrity of that DNA through precision repair processes - a new study published in Nature Cell Biology, by the research teams of Daniel Durocher and Laurence Pelletier...
Celebrating a key Canadian cancer discovery
Wednesday, December 16, 2015: McGill's Phil Gold describes the discovery of CEA 50 years ago
Flipping the repair switch to edit our genes
Wednesday, December 09, 2015: A new discovery, based on elucidating how cells control DNA repair, may be a key to editing genes directly in the human body as a means to cure or reverse disease.
Old gene’s new tricks shed light on diabetes
Monday, December 07, 2015: Dr. Drucker and his colleagues at the Lunenfeld-Tanenbaum Research Institute (LTRI) have found a surprising connection between a hormone that is produced in the gut and TCF7 – a gene previously only known to work in the immune system - in the development of diabetes.
Drug discovered in Canada now approved in Canada
Friday, December 04, 2015: ...thanks to research led by Dr. Daniel Drucker, Senior Investigator with Lunenfeld-Tanenbaum Research Institute, part of Sinai Health System, a new drug for short bowel syndrome has been approved by Health Canada.
New protein map reveals cell’s long-held secrets
Friday, December 04, 2015: A team of Toronto scientists have zoomed in on an elusive part of the cell to uncover thousands of molecular events that underlie some of the most common human diseases.
New insight into how colon cancer arises
Wednesday, October 21, 2015: In this week's issue of Nature, Dr. Alex Gregorieff and his colleagues from the laboratory of Dr. Jeff Wrana published evidence linking gut repair after damage and progression of colon cancer.
Dr. Daniel Durocher awarded prestigious cancer research prize by Memorial Sloan Kettering
Tuesday, September 29, 2015: World renowned cancer researcher Dr. Daniel Durocher has been named a recipient of the 2015 Paul Marks Prize for Cancer Research by Memorial Sloan Kettering for his research on how cells maintain the integrity of their genomes.
Lights, camera, brain action!
Thursday, September 24, 2015: Light-sensitive molecules help scientists record the first steps in making memories
How smarter mice may lead to better treatments for cognitive disorders
Friday, August 14, 2015: A new study, led by the Lunenfeld-Tanenbaum Research Institute (LTRI) and the University of Leeds, sheds light on the molecular underpinnings of learning and memory and could form the basis for research into new treatments for age-related cognitive decline, cognitive disorders such as Alzheimer’s disease and schizophrenia, and other conditions...
Governor General Announces 100 New Appointments to the Order of Canada - Congratulations to Dr. Daniel J. Drucker
Wednesday, July 01, 2015: OTTAWA—His Excellency the Right Honourable David Johnston, Governor General of Canada, announced today 100 new appointments to the Order of Canada. The new appointees include 2 Companions (C.C.), 11 Officers (O.C.) and 87 Members (C.M.).
Fetal Gender Provides Clues for the Risk of Diabetes in Women During and After Pregnancy
Thursday, May 21, 2015: A new study has found that the sex of her baby can impact a woman’s risk of developing type 2 diabetes in the first few years after pregnancy as well as her risk of having gestational diabetes in her next pregnancy.
Distinguished diabetes researcher Dr. Daniel Drucker elected to the Royal Society
Monday, May 11, 2015: One of Canada’s most celebrated researchers has been awarded yet another prestigious accolade, recognizing the powerful impact of his work on global diabetes knowledge and treatment.
New insight into stem cell reprogramming also provides new clues about a cancer-causing gene
Monday, April 20, 2015: In a new study published in the journal Genes and Development by Dr. Jeff Wrana's lab at Mount Sinai Hospital's Lunenfeld-Tanenbaum Research Institute, scientists have discovered a new series of events that is orchestrated by one of the four Yamanaka factors, called Myc. The results have potential impact for how stem cell therapies may be safely designed for clinical use.
Is using a home-based genetic test worth it...
Wednesday, April 08, 2015: Each of us has 100 or more rare gene variants that might be important. However, we don't really know yet how to perfectly calculate disease risk based on one of these. Senior LTRI Investigator Dr. Fritz Roth offers his opinion on the real value of currently available home-based genetic test kits, from the perspective of a geneticist.
The first female scientist to win Canada Gairdner Wightman Award described as a `force of nature` in stem cell biology
Thursday, March 26, 2015: Scientists and colleagues at the Lunenfeld-Tanenbaum Research Institute and Mount Sinai Hospital congratulate Dr. Janet Rossant in being named the 2015 recipient of the prestigious Canada Gairdner Wightman Award. Dr. Rossant, who is currently the Chief of Research at The Hospital for Sick Children, was one of the first cohort of researchers recruited to the newly established Mount Sinai Hospital Research Institute in 1985, where she quickly established herself as a force of nature in Canadian developmental biology.
How to best sanitize a toothbrush…and other student projects at the annual LTRI Science Fair
Friday, March 06, 2015: The fourth annual 2015 Lunenfeld-Tanenbaum Science Fair, which hosted over 39 grade seven and grade eight students from local Toronto schools on March 5, 2015, was a rocking success. At the Science Fair, students had the opportunity to present a project that delivered a solution to a scientific problem. The judging panel awarded cash prizes and medals to the top three winners in each grade.
Newly discovered actions for gut hormone GLP-1 has implications for bariatric surgery and immune disorders
Tuesday, March 03, 2015: In two papers published online today in the journals Cell Metabolism and Diabetes, Dr. Daniel Drucker's research team at Mount Sinai Hospital's Lunenfeld-Tanenbaum Research has uncovered new actions of a gut hormone which is typically targeted by drug therapies in the treatment of type 2 diabetes and obesity. In these two new studies, Dr. Drucker's team has discovered that GLP-1 has other actions in the body, in addition to stimulating insulin production, improving glucose control and helping to reduce body weight.