FEATURED PAPER
O'Donnell L, et al.
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination
Molecular Cell. 2010 Nov 24;40(4):619-31. PMID:21055983
Abstract
For an up to the moment current listing of publications, please visit PubMed lab listings.
2011
Lackner DH, Durocher D, Karlseder J.
A siRNA-Based Screen for Genes Involved in Chromosome End Protection.
PLoS One. 2011;6(6):e21407.
PMID: 21760879
Abstract
Full Text
Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F.
An allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme.
Cell. 2011 Jun 24;145(7):1075-87.
PMID: 21683433
Abstract
Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG.
MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks.
Cell Cycle. 2011 Jul 1;10(13):2218-32.
PMID: 21623170
Abstract
Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R.
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
PLoS Genetics. 2011 Apr;7(4):e1001381.
PMID: 21552324
Abstract
Full Text
Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, Sicheri F, Patterson JB.
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease.
Journal of Biological Chemistry. 2011 Apr 8;286(14):12743-55.
PMID: 21303903
Abstract
Full Text
Ito E, Yue S, Moriyama EH, Hui AB, Kim I, Shi W, Alajez NM, Bhogal N, Li G, Datti A, Schimmer AD, Wilson BC, Liu PP, Durocher D, Neel BG, O'Sullivan B, Cummings B, Bristow R, Wrana J, Liu FF.
Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.
Science Translational Medicine. 2011 Jan 26;3(67):67ra7.
PMID: 21270338
Abstract
2010
Al-Hakim A, Escribano-Diaz C, Landry MC, O'Donnell L, Panier S, Szilard RK, Durocher D.
The ubiquitous role of ubiquitin in the DNA damage response.
DNA Repair (Amst). 2010 Dec 10;9(12):1229-40. Review.
PMID: 21056014
Abstract
O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D.
The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.
Molecular Cell. 2010 Nov 24;40(4):619-31.
PMID:21055983
Abstract
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D.
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nature. 2010 Aug 19;466(7309):941-6.
PMID: 20725033
Abstract
O’Donnell L, Durocher D
DNA Repair Has a New FAN1 Club.
Molecular Cell 2010 39(2):167-169. PMID: 20670886
Abstract
Full Text
Li L, Halaby MJ, Hakem A, Cardoso R, El Ghamrasni S, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R.
Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.
Journal of Experimental Medicine. 2010 207(5):983-97. PMID: 20385750
Abstract
Zhang W, Durocher D.
De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks.
Genes & Development. 2010 24(5):502-15. PMID: 20194442
Abstract
Szilard RK, Jacques PE, Laramée L, Cheng B, Galicia S, Bataille AR, Yeung M, Mendez M, Bergeron M, Robert F, Durocher D.
Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX.
Nature Structural & Molecular Biology. 2010 17(3):299-305. PMID: 20139982
Abstract
Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP.
CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.
PLoS Biology. 2010 Jan 26;8(1):e1000286. PMID: 20126259
Full Text
Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A.
The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.
Proc Natl Acad Sci U S A. 2010 107(2):809-14. PMID: 20080757
Full Text
Lilley CE, Chaurushiya MS, Boutell C, Landry S, Suh J, Panier S, Everett RD, Stewart GS, Durocher D, Weitzman MD.
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses.
EMBO Journal. 2010 Mar 3;29(5):943-55. Epub 2010 Jan 14.PMID: 20075863
Abstract
2009
Panier S, Durocher D.
Regulatory ubiquitylation in response to DNA double-strand breaks.
DNA Repair. 2009 Apr 5;8(4):436-43.
Abstract
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Cell. 2009 Feb 6;136(3):435-46.
Abstract
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D.
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
Cell. 2009 Feb 6;136(3):420-34.
Abstract
2008
Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F.
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol Cell. 2008 Oct 24;32(2):259-75.
Dixon SJ, Fedyshyn Y, Koh JL, Prasad TS, Chahwan C, Chua G, Toufighi K, Baryshnikova A, Hayles J, Hoe KL, Kim DU, Park HO, Myers CL, Pandey A, Durocher D, Andrews BJ, Boone C.
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16653-8.
Addinall SG, Downey M, Yu M, Zubko M, Dewar J, Leake A, Hallinan J, Shaw O, James K, Wilkinson DJ, Wipat A, Durocher D, Lydall D.
A Genome-wide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae.
Genetics 2008 Oct 9. [Epub ahead of print]
Nakada S, Chen GI, Gingras AC, Durocher D.
PP4 is a gammaH2AX phosphatase required for recovery from the DNA damage checkpoint.
EMBO Rep. 2008 Oct;9(10):1019-26. Epub 2008 Aug 29.
Yeung M, Durocher D.
Engineering a DNA damage response without DNA damage.
Genome Biol. 2008;9(7):227.
Zhang W, Durocher D.
Dun1 counts on Rad53 to be turned on.
Mol Cell. 2008 Jul 11;31(1):1-2.
Fu Y, Zhu Y, Zhang K, Yeung M, Durocher D, Xiao W.
Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp.
Cell. 2008 May 16;133(4):601-11.
Macrae CJ, McCulloch RD, Ylanko J, Durocher D, Koch CA.
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.
DNA Repair (Amst). 2008 Feb 1;7(2):292-302.
2007
Kolas NK, Chapman JR , Nakada S, Ylanko Y, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase.
Science [DOI: 10.1126/science.1150034]
Abstract
Science Reprint
Kanellis P, Gagliardi M, Banath JP, Szilard RK, Nakada S, Galicia S, Sweeney FD, Cabelof DC, Olive PL, Durocher D.
A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.
PLoS Genet. 2007 Aug 10;3(8):e134.
PubMed abstract
Reprint
2006
Woolstencroft RN, Beilharz TH, Cook MA, Preiss T, Durocher D, Tyers M.
Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length.
J Cell Sci. 2006 Dec 15;119(Pt 24):5178-92.
PubMed abstract
Szilard RK, Durocher D.
Telomere protection: an act of God.
Curr Biol. 2006 Jul 25;16(14):R544-6.
PubMed abstract
Downey M, Durocher D.
GammaH2AX as a checkpoint maintenance signal.
Cell Cycle. 2006 Jul;5(13):1376-81. Epub 2006 Jul 1.
PubMed abstract
Blake D, Luke B, Kanellis P, Jorgensen P, Goh T, Penfold S, Breitkreutz BJ, Durocher D, Peter M, Tyers M.
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae.
Genetics. 2006 Jun 4.
PubMed abstract | Text on genetics.org
Kolas NK, Durocher D.
DNA repair: DNA polymerase zeta and Rev1 break in.
Curr Biol. 2006 Apr 18;16(8):R296-9.
PubMed abstract
Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D.
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.
Cell. 2006 Mar 24;124(6):1155-68.
PubMed abstract
Downey M, Durocher D.
Chromatin and DNA repair: the benefits of relaxation.
Nat Cell Biol. 2006 Jan;8(1):9-10.
Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ.
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
Nature. 2006 Jan 26;439(7075):497-501. Epub 2005 Nov 20.
PubMed abstract
2005
Sweeney FD, Yang F, Chi A, Shabanowitz J, Hunt DF, Durocher D.
Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.
Curr Biol. 2005 Aug 9;15(15):1364-75.
PubMed abstract
Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, Gray MW, Harrington LA, Hieter PA, Johnston G, Kelvin DJ, McCarry BE, Michnick SW, Ouellette F, Pearlman RE, Penn LJ, Pelletier J, Rachubinski RA, Rennie PS, Rotin D, Rottapel R, Sadowski I, Sicheri F, Siminovitch L, Sonenberg N, Siu KW, Tremblay ML, Winegarden N, Wozniak RW, Wright GD, Woodgett JR.
Problems with co-funding in Canada.
Science. 2005 Jun 24;308(5730):1867.
Bernstein NK, Williams RS, Rakovszky ML, Cui D, Green R, Karimi-Busheri F, Mani RS, Galicia S, Koch CA, Cass CE, Durocher D, Weinfeld M, Glover JN.
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Mol Cell. 2005 Mar 4;17(5):657-70.
PubMed abstract
2004
Koch CA, Agyei R, Galicia S, Metalnikov P, O'Donnell P, Starostine A, Weinfeld M, Durocher D.
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.
EMBO J. 2004 Oct 1;23(19):3874-85. Epub 2004 Sep 23.
PubMed abstract | Text on PubMed Central
2003
Kanellis P, Agyei R, Durocher D.
Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability.
Curr Biol. 2003 Sep 16;13(18):1583-95.
PubMed abstract
Durocher D, Smerdon SJ, Yaffe MB, Jackson SP.
The FHA domain in DNA repair and checkpoint signaling.
Cold Spring Harb Symp Quant Biol. 2000;65:423-31. Review.
Durocher D.
Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction.
Trends Microbiol. 2003 Feb;11(2):67-8.
2002
Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ.
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2.
Mol Cell. 2002 May;9(5):1045-54.
PubMed abstract
Durocher D, Jackson SP. Related Articles, Links
Abstract
The FHA domain.
FEBS Lett. 2002 Feb 20;513(1):58-66. Review.
PubMed abstract
Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, Yang L, Wolting C, Donaldson I, Schandorff S, Shewnarane J, Vo M, Taggart J, Goudreault M, Muskat B, Alfarano C, Dewar D, Lin Z, Michalickova K, Willems AR, Sassi H, Nielsen PA, Rasmussen KJ, Andersen JR, Johansen LE, Hansen LH, Jespersen H, Podtelejnikov A, Nielsen E, Crawford J, Poulsen V, Sorensen BD, Matthiesen J, Hendrickson RC, Gleeson F, Pawson T, Moran MF, Durocher D, Mann M, Hogue CW, Figeys D, Tyers M.
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Nature. 2002 Jan 10; 415(6868):180-3
PubMed abstract
2001
Durocher D and Jackson SP.
DNA-PK, ATM and ATR, variations on a theme?
Curr Opin Cell Biol . 2001 Apr 13 (2):225-31. Review.
PubMed abstract
2000
Durocher D., Yaffe MB and Jackson SP.
Regulation of DNA damage signalling by FHA domains.
Cold Spring Harbor Symposia on Quantitative Biology (2000) Review.
Durocher D, Taylor IA, Sarbassova D, Haire LH, Westcott SL, Jackson SP, Smerdon SJ and Yaffe MB.
The molecular basis of FHA domain: phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Molecular Cell. 2000, 6:1169-1182
PubMed abstract | Text on molecule.org
1999
Durocher D, Henckel J, Fersht A, Jackson SP.
The FHA domain is a modular phosphopeptide recognition motif.
Molecular Cell. 1999, 4:387-394
PubMed abstract | Text on molecule.org