LunenfeldR. J. Hung Lab
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Integrative Molecular Epidemiology Research Group

Selected Publications

  1. Hung RJ, Gazdar AF (2020). Lung Cancer - Continues to be the leading cause of cancer death. In: Wild CP, Weiderpass E, Stewart BW, editors. World Cancer Report: Cancer Research for Cancer Prevention. Lyon, France: International Agency for Research on Cancer. Available from: http://publications.iarc.fr/586.
     
  2. Thomas S, Carroll JC, Brown MC, Chen Z, Mirshams M, Patel D, Boyd K, Pierre A, Goldstein DP, Giuliani ME, Xu W, Eng L, Khodayari Moez E, Liu G, Hung RJ. Nicotine dependence as a risk factor for upper aerodigestive tract (UADT) cancers: A mediation analysis. PLoS One. 2020 Aug 28;15(8):e0237723. doi: 10.1371/journal.pone.0237723
     
  3. Lee SM, Mitchell R, Knight JA, Mazzulli T, Relton C, Khodayari-Moez E, Hung RJ. Early Childhood Cytomegalovirus (CMV) Infection and Children’s Neurocognitive Development.  International Journal of Epidemiololgy, in press
     
  4. Brhane Y, Yang P, Christiani DC, Liu G, McLaughlin JR, Brennan P, Shete S, Field JK, Tardón A, Kohno T, Shiraishi K, Matsuo K, Bosse Y, Amos CI, Hung RJ. Genetic determinants of lung cancer prognosis in never smokers: A pooled analysis in the International Lung Cancer Consortium. Cancer Epidemiology, Biomarker and Prevention. Cancer Epidemiol Biomarkers Prev. 2020 Jul 22. doi: 10.1158/1055-9965.EPI-20-0248.
     
  5. Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V, Caporaso NE, Landi MT, Christiani DC, Vineis P, Liu G, Scelo G, Zaridze D, Shete SS, Albanes D, Aldrich MC, Tardón A, Rennert G, Chen C, Goodman GE, Doherty JA, Bickeböller H, Field JK, Davies MP, Dawn Teare M, Kiemeney LA, Bojesen SE, Haugen A, Zienolddiny S, Lam S, Le Marchand L, Cheng I, Schabath MB, Duell EJ, Andrew AS, Manjer J, Lazarus P, Arnold S, McKay JD, Emami NC, Warkentin MT, Brhane Y, Obeidat M, Martin RM, Relton C, Davey Smith G, Haycock PC, Amos CI, Brennan P, Witte JS*, Hung RJ*. Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility. Nature Communications. 2020, 11(1):27. doi: 10.1038/s41467-019-13855-2.– Selected as Editor’s Highlights of the month.
     
  6. Arneja J, Hung RJ, Seeto RA, Knight JA, Hewko SL, Bocking A, Lye SJ, Brooks JD. Association between maternal acetaminophen use and adverse birth outcomes in a pregnancy and birth cohort.  Pediatr Res. 2019 Dec 18. doi: 10.1038/s41390-019-0726-8.
     
  7. Warkentin MT, Lam S, Hung RJ. Determinants of impaired lung function and lung cancer prediction among never-smokers in the UK Biobank cohort. EBioMedicine-published by Lancet. 47:58-64. 2019
     
  8. Shepshelovich D, Xu W, Lu L, Fares A, Yang P, Christiani D, Zhang J, Shiraishi K, Ryan BM, Chen C, Schwartz AG, Tardon A, Wu X, Schabath MB, Teare MD, Le Marchand L, Zhang ZF, Field JK, Brenner H, Diao N, Xie J, Kohno T, Harris CC, Wenzlaff AS, Fernandez-Tardon G, Ye Y, Taylor F, Wilkens LR, Davies M, Liu Y, Barnett MJ, Goodman GE, Morgenstern H, Holleczek B, Brown MC, Liu G*, Hung RJ*. Body mass index (BMI), BMI change, and overall survival in small cell and non-small cell lung cancer patients: a pooled analysis of the International Lung Cancer Consortium.  J. Thoracic Oncology, 14(9):1594-1607, 2019
     
  9. Hung RJ, Spitz MR, Houlston RS, Schwartz AG, Field JK, Ying J, Li Y, Han Y, Ji X, Chen W, Wu X, Gorlov IP, Na J, de Andrade M, Liu G, Brhane Y, Diao N, Wenzlaff A, Davies MP, Liloglou T, Timofeeva M, Muley T,  Rennert H, Saliba W, Ryan BM, Bowman E, Barros-Dios J, Pérez-Ríos M, Morgenstern H, Zienolddiny S, Skaug V, Ugolini D, Bonassi S, van der Heijden EHFM, Tardon A, Bojesen SE, Landi MT, Johansson M, Bickeböller H, Arnold S, Le Marchand L, Melander O, Andrew A, Grankvist K, Caporaso N, Teare MD, Schabath MB, Aldrich MC, Kiemeney LA, Wichmann HE, Lazarus P, Mayordomo J, Neri M, Haugen A, Zhang ZF, Ruano-Raviña A, Brenner H, Harris CC, I Orlow, Rennert G, Risch A, Brennan P, Christiani DC, Amos CI, Yang P, Gorlova OY. Lung cancer risk in never smokers of European descents is associated with genetic variation in the 5p15.33 TERT-CLPTM1L region. Journal of Thoracic Oncology, 14(8):1360-1369 2019, doi: 10.1016/j.jtho.2019.04.008.
     
  10. Kachuri L, Helby J, Bojesen SE, Christiani DC, Su L, Wu X, Tardón A, Fernández-Tardón G, Field JK, Davies MP, Chen C, Goodman GE, Shepherd FA, Leighl NB, Tsao MS , Brhane Y, Brown MC, Boyd K, Shepshelovich D, Sun L, Amos CI, Liu G, Hung RJ. Investigation of leukocyte telomere length and genetic variants in chromosome 5p15.33 as prognostic markers in lung cancer.  Cancer Epidemiology, Biomarker and Prevention.  2019, 28(7):1228-1237
     
  11. Shen SY*, Singhania R*, Fehringer G*, Chakravarthy A*, Roehrl MHA, Chadwick D, Zuzarte PC, Borgida A, Wang TT, Li T, Kis O, Zhao Z, Spreafico A, Medina TDS, Wang Y, Roulois D, Ettayebi I, Chen Z, Chow S, Murphy T, Arruda A, O'Kane GM, Liu J, Mansour M, McPherson JD, O'Brien C, Leighl N, Bedard PL, Fleshner N, Liu G, Minden MD, Gallinger S, Goldenberg A, Pugh TJ, Hoffman MM, Bratman SV, Hung RJ*, De Carvalho DD*. Sensitive tumour detection and classification using plasma cell-free DNA methylomes.
    Nature. 2018 Nov 14. doi: 10.1038/s41586-018-0703-0.
     
  12. Kachuri, L; Saarela, O; Bojesen, SE; Davey Smith, G; Liu, G; Landi, MT; Caporaso, NE; Christiani, DC; Johansson, M; Panico, S; Overvad, K; Trichopoulou, A; Vineis, P; Scelo, G; Zaridze, D; Wu, X; Albanes, D; Diergaarde, B; Lagiou, P; Macfarlane, GJ; Aldrich, MC; Tardón, A; Rennert, G; Olshan, AF; Weissler, MC; Chen, C; Goodman, GE; Doherty, JA; Ness, AR; Bickeböller, H; Wichmann, HE; Risch, A; Field, JK; Teare, MD; Kiemeney, LA; van der Heijden, EHFM; Carroll, JC; Haugen, A; Zienolddiny, S; Skaug, V; Wünsch-Filho, V; Tajara, EH; Ayoub Moysés, R; Daumas Nunes, F; Lam, S; Eluf-Neto, J; Lacko, M; Peters, WHM; Le Marchand, L; Duell, EJ; Andrew, AS; Franceschi, S; Schabath, MB; Manjer, J; Arnold, S; Lazarus, P; Mukeriya, A; Swiatkowska, B; Janout, V; Holcatova, I; Stojsic, J; Mates, D; Lissowska, J; Boccia, S; Lesseur, C; Zong, X; McKay, JD; Brennan, P; Amos, CI; Hung, RJ. Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers. Int J Epidemiol. 2018 Jul 28. doi: 10.1093/ije/dyy140. [Epub ahead of print] PMID 30059977
     
  13. McKay JD*, Hung RJ*, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE, Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva MN, Bojesen SE, Wu X, Le Marchand L, Albanes D, Bickeböller H, Aldrich MC, Bush WS, Tardon A, Rennert G, Teare MD, Field JK, Kiemeney LA, Lazarus P, Haugen A, Lam S, Schabath MB, Andrew AS, Shen H, Hong YC, Yuan JM, Bertazzi PA, Pesatori AC, Ye Y, Diao N, Su L, Zhang R, Brhane Y, Leighl N, Johansen JS, Mellemgaard A, Saliba W, Haiman CA, Wilkens LR, Fernandez-Somoano A, Fernandez-Tardon G, van der Heijden HFM, Kim JH, Dai J, Hu Z, Davies MPA, Marcus MW, Brunnström H, Manjer J, Melander O, Muller DC, Overvad K, Trichopoulou A, Tumino R, Doherty JA, Barnett MP, Chen C, Goodman GE, Cox A, Taylor F, Woll P, Brüske I, Wichmann HE, Manz J, Muley TR, Risch A, Rosenberger A, Grankvist K, Johansson M, Shepherd FA, Tsao MS, Arnold SM, Haura EB, Bolca C, Holcatova I, Janout V, Kontic M, Lissowska J, Mukeria A, Ognjanovic S, Orlowski TM, Scelo G, Swiatkowska B, Zaridze D, Bakke P, Skaug V, Zienolddiny S, Duell EJ, Butler LM, Koh WP, Gao YT, Houlston RS, McLaughlin J, Stevens VL, Joubert P, Lamontagne M, Nickle DC, Obeidat M, Timens W, Zhu B, Song L, Kachuri L, Artigas MS, Tobin MD, Wain LV; SpiroMeta Consortium, Rafnar T, Thorgeirsson TE, Reginsson GW, Stefansson K, Hancock DB, Bierut LJ, Spitz MR, Gaddis NC, Lutz SM, Gu F, Johnson EO, Kamal A, Pikielny C, Zhu D, Lindströem S, Jiang X, Tyndale RF, Chenevix-Trench G, Beesley J, Bossé Y, Chanock S, Brennan P, Landi MT, Amos CI. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet. 2017 Jul;49(7):1126-1132. doi: 10.1038/ng.3892 PMID: 28604730    
     
  14. Hung RJ, Fehringer G, Casey F, Gruber SB, Peters U, Goode EL, Sellers TA, Haiman CA, Hunter DJ, Kraft P, Amos CI, Freedman ML, Wilson MD. Cross-Cancer Analysis Reveals Novel Pleiotropic Associations – Reply. Cancer Res. 2017 Nov 1;77(21):6045-6046
     
  15. Zong X, Pole JD, Grundy PE, Mahmud, SM, Parker L, Hung RJ. Second Malignant Neoplasms after Childhood Non-CNS Embryonal Tumors in North America: a population-based study. European Journal of Cancer, 2017 84C:173-183. 
     
  16. Fehringer G, Brenner DR, Zhang ZF, Lee YA, Matsuo K, Ito H, Lan Q, Vineis P, Johansson M, Overvad K, Riboli E, Trichopoulou A, Sacerdote C, Stucker I, Boffetta P, Brennan P, Christiani DC, Hong YC, Landi MT, Morgenstern H, Schwartz AG, Wenzlaff AS, Rennert G, McLaughlin JR, Harris CC, Olivo-Marston S, Orlow I, Park BJ, Zauderer M, Barros Dios JM, Ruano Raviña A, Siemiatycki J, Koushik A, Lazarus P, Fernández-Somoano A, Tardon A, Le Marchand L, Brenner H, Saum KU, Duell EJ, Andrew AS, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Holcatova I, Pesatori AC, Consonni D, Olsson A, Straif K, Hung RJ.  Alcohol and Lung Cancer Risk Among Never Smokers: A Pooled Analysis from the International Lung Cancer Consortium and the SYNERGY Study.  International J. Cancer, 2017
     
  17. Fehringer G, Kraft P, Pharoah PD, Eeles RA, Chatterjee N, Schumacher FR, Schildkraut JM, Lindstrom S, Brennan P, Bickeböller H, Houlston RS, Landi MT, Caporaso NE, Risch A, Amin Al Olama A, Berndt SI, Giovannucci E, Gronberg H, Kote-Jarai Z, Ma J, Muir K, Stampfer MJ, Stevens VL, Wiklund F, Willett WC, Goode EL, Permuth JB, Risch HA, Reid BM, Bezieau S, Brenner H, Chan AT, Chang-Claude J, Hudson TJ, Kocarnik J, Newcomb PA, Schoen RE, Slattery ML, White E, Adank MA, Ahsan H, Aittomaki K, Baglietto L, Blomquist C, Canzian F, Czene K, Dos Santos Silva I, Eliassen AH, Figueroa JD, Flesch-Janys D, Fletcher O, Garcia-Closas M, Gaudet MM, Johnson N, Hall P, Hazra A, Hein R, Hofman A, Hopper JL, Irwanto A, Johansson M, Kaaks R, Kibriya MG, Lichtner P, Liu JJ, Lund E, Makalic E, Meindl A, Müller-Myhsok B, Muranen TA, Nevanlinna H, Peeters PH, Peto J, Prentice RL, Rahman N, Sanchez MJ, Schmidt DF, Schmutzler RK, Southey MC, Tamimi RM, Travis RC, Turnbull C, Uitterlinden AG, Wang Z, Whittemore AS, Yang XR, Zheng W, Rafnar T, Gudmundsson J, Stacey SN, Stefansson K, Sulem P, Chen YA, Tyrer JP, Christiani DC, Wei Y, Shen H, Hu Z, Shu XO, Shiraishi K, Takahashi A, Bossé Y, Obeidat M, Nickle D, Timens W, Freedman ML, Li Q, Seminara D, Chanock SJ, Gong J, Peters U, Gruber SB, Amos CI, Sellers TA, Easton DF, Hunter DJ, Haiman CA, Henderson BE, Hung RJ. Cross-cancer genome-wide association analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations. Cancer Research, 2016, 76(17):5103-14
     
  18. Kachuri L, Latifovic L, Liu G, Hung RJ. Systematic review of genetic variation in chromosome 5p15.33 and telomere length as predictive and prognostic biomarkers for lung cancer. Cancer Epidemiol Biomarkers Prev. 2016 25(12):1537-1549.
     
  19. Kachuri L, Amos CI, McKay JD, Johansson M, Vineis P, Bueno-de-Mesquita HB, Boutron-Ruault M, Johansson M, Quirós JR, Sieri S, Travis RC, Weiderpass E, Le Marchand L, Henderson BE, Wilkens L,  Goodman G, Chen C, Doherty JA, Christiani DC, Wei Y, Su L, Tworoger S, Kraft P, Zaridze D, Field JK, Marcus MW, Davies MPA, Hyde R, Caporaso NE, Landi MT, Severi G, Giles GG, Liu G, McLaughlin JR, Li Y, Xiao X, Fehringer G, Zong X, Denroche RE, Zuzarte PC, McPherson JD, Brennan P, Hung RJ. Fine-mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci. Carcinogenesis. 2016, 37(1):96-105.
     
  20. Hung RJ, Ulrich CM, Goode EL, Brhane Y, Muir K, Chan AT, Le Marchand L, Schildkraut J, Witte J S., Eeles R, Boffetta P., Spitz MR, Poirier JG, Rider DN, Fridley BL, Chen Z, Haiman C, Schumacher F, Easton DF, Landi MT, Brennan P, Houlston R, Christiani D., Field JK, Bickeboller H., Risch A, Kote-Jarai Z., Wiklund F, Gronberg H, Chanock S, Berndt SI, Kraft P, Lindstrom S, Al Olama AA, Song H, Phelan C, Wentzensen N, Peters U, Slattery ML, Sellers TA, Gruber SB, Hunter DJ, Amos CI & Henderson B. Cross Cancer Genomic Investigation of Inflammation Pathway Based on Five Common Cancers: Lung, Ovary, Prostate, Breast and Colorectal Cancer. Journal of the National Cancer Institute, 2015 107 (11): djv246. doi: 10.1093/jnci/djv246
     
  21. Brenner DB, Amos CI, Brhane Y, Timofeeva MN, Caporaso N, Wang Y, Christiani DC, Bickeböller H, Yang P, Albanes D, Stevens VL, Gapstur S, McKay J, Boffetta P, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Skorpen F, Gabrielsen ME, Vatten L, Njølstad I, Chen C, Goodman G, Lathrop M, Vooder T, Välk K, Nelis M, Metspalu A, Broderick P, Eisen T, Wu X, Zhang D, Chen W, Spitz MR, Wei Y, Su L, Xie D, She J, Matsuo K, Matsuda F, Ito H, Risch A, Heinrich J, A Rosenberger, Muley T, Dienemann H, Field JK, Raji O, Chen Y, Gosney J, Liloglou T, Davies MPA, Marcus M ,McLaughlin J, Orlow I, Han Y, Li Y,  Zong Z, Johansson M and EPIC Investigators, Liu G, Tworoger SS, Le Marchand L, Henderson BE, Wilkens LR, Dai J, Shen H, Houlston RS, Landi MT, Brennan P, Hung RJ. Identification of lung cancer histology-specific variants applying Bayeisan framework variant prioritization approaches within the TRICL and ILCCO consortia.  Carcinogenesis,  2015. 36(11):1314-26. (10.1093/carcin/bgv128)
     
  22. Poirier JG, Brennan P, McKay JD, Spitz MR, Bickeböller H, Risch A, Liu G, Le Marchand L, Tworoger S, McLaughlin J, Rosenberger A, Heinrich J, Brüske I, Muley, Henderson BE, Wilkens LR, Zong X,  Li Y, Hao K, Timens W, Bossé Y, Sin DD, Obeidat M,  Amos CI, Hung RJ. Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer.  Genetic Epidemiology, 2015, 39(3):197-206
     
  23. Chen LS, Hung RJ, Baker T, Horton A, Culverhouse R, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J,  Kim C, Lutz S, Rosenberger A, Aben KK, Chang SC, Dieffenbach AK, Dienemann H, Brittni Fredericksen H, Han J, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden HF, Wamplfer J, Wenzlaff A, Woll P,  Zienolddiny S, Bickeböller H, Brenner H, Haugen A,  Heinrich J, Hokanson J,  Hunter D, Kiemeney LA, Le Marchand L,  Liu G,  Mayordomo J, Risch A. Schwartz A, Teare D, Wu X, Wiencke JK, Yang P, Zhang ZF, Spitz M, Kraft P,  Amos CI, Bierut LJ. CHRNA5 risk variant predicts earlier age at lung cancer diagnosis and delayed smoking cessation- a meta-analysis. JNCI, 107(5), 2014. doi: 10.1093/jnci/djv100
     
  24. Kim CH, Lee YC, Hung RJ, McNallan SR, Cote ML, Lim WY, Chang SC, Kim JH, Ugolini D, Chen Y, Liloglou T, Andrew AS, Onega T, Duell EJ, Field JK, Lazarus P, Le Marchand L, Neri M, Vineis P, Kiyohara C, Hong YC, Morgenstern H, Matsuo K, Tajima K, Christiani DC, McLaughlin JR, Bencko V, Holcatova I, Boffetta P, Brennan P, Fabianova E, Foretova L, Janout V, Lissowska J, Mates D, Rudnai P, Szeszenia-Dabrowska N, Mukeria A, Zaridze D, Seow A, Schwartz AG, Yang P, Zhang ZF, et al.  Exposure to secondhand tobacco smoke and lung cancer by histological subtype: a pooled analysis of the International Lung Cancer Consortium (ILCCO). IJC, 2014, 135(8):1918-30. 
     
  25. Zhang LR, Morgenstern H, Greenland S, Chang SC, Lazarus P, Teare MD, Woll PJ, Orlow I, Cox B, Brhane Y, Liu G, Hung RJ.  Cannabis smoking and lung cancer risk: pooled analysis in the International Lung Cancer Consortium. International Journal of Cancer, 2015 136(4):894-903
     
  26. Brenner DR, Scherer D, Muir K, Schildkraut J, Boffetta P, Spitz M, LeMarchand L, Chan AT, Goode EL, Ulrich CM, Hung RJ.  A review of the application of inflammatory biomarkers in epidemiologic cancer research. CEBP, 23(9):1729-1751.  2014 
     
  27. Fehringer G, Gallinger S, Borgida A, Zhang LR, Adams L, Liu G, Hung RJ.  The association of family history of cancer and medical history with pancreatic cancer risk.  Journal of Pancreas.  43(5):812-4. 2014.
     
  28. Zuzarte PC, Denroche RE, Fehringer G, Katzov-Eckert H, Hung RJ, McPherson JD. A two-dimensional pooling strategy for rare variant detection on next-generation sequencing platforms. PLoS ONE. 2014 Apr 11;9(4):e93455.
     
  29. Brenner DR, Brennan P, Boffetta P, Amos C, Spitz M, Chen C, Goodman G, Wichmann E, Bickeboller H, Risch A, McLaughlin JR, Benhamou S, Lewinger JP, Witte JS, Chen G, Bull S, Hung RJ. Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls. Human Genetics, 132(5):579-89, 2013.(EGRP Top 10 Research Highlights in 2013)
     
  30. Zhang LR, Sawka AM, Adams L, Hatfield N. Hung RJ.  Vitamin and mineral supplements and thyroid cancer: a systematic review.  European Journal of Cancer Prevention. 2013, 22(2):158-68.
     
  31. Brenner DR, Boffetta P, Duell EJ, Bickeböller H, Rosenberger A, McCormack V, Muscat JE, Yang P, Wichmann HE, Brueske-Hohlfeld I, Schwartz AG, Cote ML, Tjønneland A, Friis S, Le Marchand L, Zhang ZF, Morgenstern H, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Foretova L, Janout V, Bencko V, Schejbalova M, Brennan P, Mates IN, Lazarus P, Field JK, Raji O, McLaughlin JR, Liu G, Wiencke J, Neri M, Ugolini D, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Hung RJ. Previous lung disease and lung cancer risk: a pooled analysis from the international lung cancer consortium.  AJE, 2012 176 (7): 573-85
     
  32. Timofeeva MN, Hung RJ, Rafnar T, Christiani DC, Field JK, Bickeboller H, Risch A, McKay JD, Wang Y, Dai J, Gaborieau V, McLaughlin J, Brenner D, Narod S, Caporaso NE, Albanes D, Thun M, Eisen T, Wichmann HE, Rosenberger A, Han Y, Chen W, Zhu D, Spitz M, Wu X, Pande M, Zhao Y, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Krokan HE, Gabrielsen ME, Skorpen F, Vatten L, Njølstad I, Chen C, Goodman G, Lathrop M, Benhamou S, Vooder T, Välk K, Nelis M, Metspalu A, Raji O, Chen Y, Gosney J, Liloglou T, Muley T, Dienemann H, Thorleifsson G, Shen H, Stefansson K, Brennan P, Amos CI, Houlston R, Landi MT; for TRICL Research Team.  Influence of Common Genetic Variation on Lung Cancer Risk: Meta-Analysis of 14,900 Cases and 29,485 Controls.  Human Molecular Genetics, 2012, 21(22):4980-95.
     
  33. Fehringer G, Liu G, Pintilie M, Sykes J, Cheng D, Liu X, Chen Z, Seymour L, Der SD, Shepherd FA, Tsao MS, Hung RJ.  Association of the 15q25 and 5p15 lung cancer susceptibility regions with gene expression in lung tumor tissues.  CEBP 21(7):1097-104, 2012.
     
  34. Rosenberger A, Bickeböller H, McCormack V, Brenner DR, Duell EJ, Tjønneland A, Friis S, Muscat JE, Yang P, Wichmann HE, Heinrich J, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Janout V, Bencko V, Brennan P, Mates D, Schwartz AG, Cote ML, Zhang ZF, Morgenstern H, Oh SS, Field JK, Raji O, McLaughlin JR, Wiencke J, Lemarchand L, Neri M, Bonassi S, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Boffetta P, Hung RJ. Asthma and Lung Cancer Risk: A Systematic Investigation by the International Lung Cancer Consortium. Carcinogenesis 2012,33(3):587-97. 
     
  35. Cote ML, Liu M, Bonassi S, Neri M, Schwartz AG, Christiani DC, Spitz MR, Muscat JE, Rennert G, Andrew AS, Bencko V, Bickeböller H, Boffetta P, Brennan P, Brenner H, Duell EJ, Fabianova E, Field JK, Foretova L, Friis S, Harris CC, Holcatova I, Hong YC, Isla D, Janout V, Kiemeney LA, Kiyohara C, Lan Q, Lazarus P, Lissowska J, Le Marchand L, Mates D, Matsuo K, I. Mayordomo JI, McLaughlin JR, Morgenstern H, Müller H, Orlow I , Park BJ, Raji OY, Rudnai P, Seow A, Stucker I, Szeszenia-Dabrowska N, Teare MD, Tjønnelan A, Ugolini D, van der Heijden HFM, Wichmann E, Wiencke JK, Woll PJ, Yang P, Zaridze D, Zhang ZF, Etzel CJ, Hung RJ. Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium. European Journal of Cancer, 2012 48(13):1957-68. 
     
  36. Brenner DR, Boffetta P, Duell EJ, Bickeböller H, Rosenberger A, McCormack V, Muscat JE, Yang P, Wichmann HE, Brueske-Hohlfeld I, Schwartz AG, Cote ML, Tjønneland A, Friis S, Le Marchand L, Zhang ZF, Morgenstern H, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Foretova L, Janout V, Bencko V, Schejbalova M, Brennan P, Mates IN, Lazarus P, Field JK, Raji O, McLaughlin JR, Liu G, Wiencke J, Neri M, Ugolini D, Andrew AS, Lan Q, Hu W, Orlow I, Park BJ, Hung RJ. Previous lung disease and lung cancer risk: a pooled analysis from the international lung cancer consortium. AJE, 2012 176 (7): 573-85
     
  37. Fehringer G, Liu G, Briollais L, Brennan P, Amos CI, Spitz MR, Bickeböller H, Wichmann HE, Risch A, Hung RJ. Comparison of pathway analysis approaches using lung cancer GWAS data sets. PLoS ONE, 2012, 2012;7(2):e31816. 
     
  38. McCormack V, Hung RJBrenner DR, Bickeböller H, Rosenberger A, Muscat JE, Lazarus P, Tjønneland A, Friis S, Christiani DC, Chun E, Le Marchand L, Rennert G, Rennert HS, Andrew AS, Orlow I, Park P, Boffetta P, Duell EJ. Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO). Cancer Causes and Controls, 2011, 22(12):1709-20. 
     
  39. Brenner DB, McLaughlin JR, Hung RJ. Previous lung diseases and lung cancer: A systematic review and meta-analysis. PLoS ONE, 2011, 31;6(3):e17479. 
     
  40. Brenner DRHung RJ, Tsao M, Shepherd F, Johnston M, Narod S, Rubenstein W, McLaughlin JR. Lung Cancer Risk in Toronto, Ontario Canada: A Population-based Case-Control Study of Epidemiologic Risk Factors. BMC Cancer. 2010 Jun 14;10(1):285 
     
  41. Chu A, Heck JE, Ribeiro KR, Brennan P, Boffetta P, Buffler P, Hung RJ. Wilms tumor: A systematic review and meta–analysis. Pediatric and Perinatal Epidemiology, 2010 Sep;24(5):449-69. 
     
  42. Truong T, Sauter W, McKay JD, Hosgood HD III, Gallagher C, Amos CI, Spitz M, Muscat J, Lazarus P, Illig T, Wichmann HE, Bickeboeller H, Risch A, Dienemann H, Zhang ZF, Naeim BP, Yang P, Zienolddiny S, Haugen A, Le Marchand L, Hong YC, Kim JH, EJDuell, Andrew AS, Kiyohara C, Shen H, Matsuo K, Suzuki T, Seow A, Ng DPK, Lan Q, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Constantinescu V, Bencko V, Foretova L, Janout V, Chabrier A, Boffetta P, Brennan P and Hung RJ. International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. Carcinogenesis, 2010 Apr;31(4):625-33 
     
  43. Truong T, Hung RJ, Amos CI, Wu X, Bickeböller H, Rosenberger A, Sauter W, Illig T, Wichmann HE, Risch A, Dienemann H, Kaaks R, Yang P, Jiang R, Wiencke JK, MWrensch W, Hansen H, Kelsey KT, Keitaro Matsuo K, Tajima K, Schwartz AG, Wenzlaff A, Seow A, Ying C, Staratschek-Jox A, Nürnberg P, EStoelben E, Wolf J, Lazarus P, Muscat JE, Gallagher C, Zienolddiny S, Haugen A, van der Heijden HFM, LKiemeney LA, Isla D, Mayordomo JI, Rafnar T, Kari, Stefansson K, Zuo-Feng Zhang ZF, Chang SC, Kim JH, Hong YC, Duell EJ, Andrew AS, Lejbkowicz F, Rennert G, Müller H, Brenner, Le Marchand L, Benhamou S, Bouchardy C, Teare MD, Xue X, McLaughlin J, Liu G, McKay J, Brennan P1,Spitz M. International Lung Cancer Consortium: Replication of susceptibility loci on chromosome 15q25, 5p15 and 6p21. JNCI 102(13):959-71, 2010 
     
  44. Wakefield J, De Vocht F, Hung RJ. Bayesian Mixture Modeling of Gene-Environment and Gene-Gene Interactions. Genetic Epidemiology. Genet Epidemiol. 2010 Jan;34(1):16-25. 
     
  45. Vaissière T, Hung RJ, Zaridze D, Moukeria A, Cuenin C, Fasolo V, Ferro G, Paliwal A, Hainaut P, Brennan P, Tost J, Boffetta P, Herceg Z. Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. Cancer Res. 2009;69(1):243-52. 
     
  46. Boccia S, Boffetta P, Brennan P, Ricciardi G, Gianfagna F, Matsuo K, van Duijn CM, Hung RJ. Meta-analyses of the Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and risk of head and neck and lung cancer. Cancer Lett. 2009, 273(1):55-61. PMID: 18789576 [senior author] 
     
  47. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chen C, Goodman G, Field JK, Liloglou T, Xinarianos G, Cassidy A, McLaughlin J, Liu G, Narod S, Krokan HE, Skorpen F, Elvestad MB, Hveem K, Vatten L, Linseisen J, Clavel-Chapelon F, Vineis P, Bueno-de-Mesquita HB, Lund E, Martinez C, Bingham S, Rasmuson T, Hainaut P, Riboli E, Ahrens W, Benhamou S, Lagiou P, Trichopoulos D, Holcátová I, Merletti F, Kjaerheim K, Agudo A, Macfarlane G, Talamini R, Simonato L, Lowry R, Conway DI, Znaor A, Healy C, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008;452(7187):633-7 PMID: 18385738 [first author] 
     
  48. McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod, S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Njolstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubinski J, Matyjasik J, Lener M, Oszutowska D, Field JK, Liloglou T, Xinarianos G, Cassidy A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P. Lung cancer susceptibility locus at 5p 15.33. Nat Genet. 2008;40(12):1404-6.
     
  49. Hung,RJ, Christiani,D.C., Risch,A., Popanda,O., Haugen,A., Zienolddiny,S., Benhamou,S., BOUCHARDY,C., Lan,Q., Spitz,M.R., Wichmann,H.E., Le Marchand,L., Vineis,P., Matullo,G., Kiyohara,C., Zhang,Z.F., Pezeshki,B., Harris,C., Mechanic,L., Seow,A., Ng,D.P.K., Szeszenia-Dabrowska,N., Zaridze,D., Lissowska,J., Rudnai,P., Fabianova,D., Mates,D., Foretova,L., Janout,V., Bencko,V., Caporaso,N., Chen,C., Duell,E.J., Goodman,G., Field,J.K., Houlston,R.S., Hong,Y.C., Landi,M.T., Lazarus,P., Muscat,J., McLaughlin,J., Schwartz,A.G., Shen,H., Stucker,I., Tajima,K., Matsuo,K., Thun,M., Yang,P., Wiencke,J., Andrew,A.S., Monnier,S., Boffetta,P., and Brennan,P. (2007) International Lung Cancer Consortium: Pooled analysis of sequence variants in DNA repair and cell cylce pathways. Cancer Epi.Biomarker Prev., 2008 Nov;17(11):3081-9. 
     
  50. Hung RJ, Moore L, Boffetta P, Feng BJ, Toro J, Rothman N, Zaridze D, Navratilova M, Bencko V, Janout V, Kollarova H, Szeszenia-Dabrowska N, Mates D, Chow WH, Brennan P. Family History and the Risk of Kidney Cancer : A Multicenter Case-control Study in Central Europe. CEBP. 2007 Jun;16(6):1287-90. PMID: 17548699 
     
  51. Hung RJ, Hashibe M, McKay J, Gaborieau V, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates I, Foretova L, Janout V, Bencko V, Chabrier, Moullan N, Canzian F, Hall J, Boffetta P, Brennan P. Folate related genes and the risk of tobacco-related cancers in Central Europe. Carcinogenesis, 2007, 28(6):1334-40. 
     
  52. Hung RJ, Baragatti M, Thomas D, McKay J, Szeszenia-Dabrowska N , Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Moullan N, Canzian F, Hall J, Boffetta P, Brennan P. Inherited Predisposition of Lung Cancer: A Hierarchical Modeling Approach to DNA repair and Cell Cycle Control Pathways. CEBP 2007;16(12):2736–44. 
     
  53. Brennan, P., McKay, J., Moore, L., Zaridze, D., Mukeria, A., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Bencko, V., Foretova, L., Janout, V., Chow, W. H., Rothman, N., Chabrier, A., Gaborieau, V., Odefrey, F., Southey, M., Hashibe, M., Hall, J., Boffetta, P., Peto, J., Peto, R., and Hung, RJ. Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study. 2007.Hum. Mol. Genet., 16: 1794-1801 
     
  54. Hung RJ, Boffetta P, Canzian F, Moullan N, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Stefano Landi, Federica Gemignani , Hall J, Brennan P. Sequence variants in cell cycle control pathway, X-ray exposures and lung cancer risk: a multicenter case-control study in Central Europe. Cancer Research, 2006. 66(16):8280-6. 
     
  55. Hung RJ, Brennan P, Canzian F, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Borel S, Hall J, Boffetta P. Large-Scale Investigation of Base Excision Repair Genetic Polymorphisms and Lung Cancer Risk in a Multicenter Study. JNCI 2005. 97(8): 567-576. 
     

 

  
  
      
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