Physiological Testing of Mutant Mice Generated by Random Mutagenesis or Other Methods

Powerful techniques for genetic manipulation in the mouse have led to unparalleled progress in the task of assigning function to the ~24,000 genes of the mammalian genome. A major goal of our lab is to use equally powerful and accessible tools for evaluating physiologic function in mice in order to accelerate this task. In the Centre for Modeling Human Disease (CMHD) Mouse Physiology Laboratory at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital (www.cmhd.ca), we perform high-throughput tests for cardiovascular, renal, skeletal, neurobehaviour, eye and hematologic function to identify new genes that may underlie important human diseases. Such tests are also being used to discover genes important in the mother, placenta, and fetus throughout development and pregnancy.