For the most recent publication listing, please visit the PubMed lab listing

Selected publications:

OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Juang Y-C, Landry M-C, Sanches M, Vittal V, Charles L, Ceccarelli D, Mateo A-RF, Pruneda JN, Mao D, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D. (2012) Mol Cell. (in press)

Tang X, Orlicky S, Mittag T, Csizmok V, Pawson T, Forman-Kay JD, Sicheri F, Tyers M. Composite low affinity interactions set a phosphorylation threshold for recognition of the Sic1 CDK inhibitor by the SCFCdc4 ubiquitin ligase.  (2011) PNAS.  (in press)

Guettler S, Larose J, Petsalaki E, Gish G, Scotter A, Pawson T, Rottapel R, Sicheri F. Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.  (2011) Cell, 147, 1340-54.

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F. An Allosteric Inhibitor of the Human Cdc34 Ubiquitin Cojugating Enzyme. (2011) Cell, 145, 1075-87.

Dey M, Velyvis A, Li JJ, Chiu E, Chiovitti D, Kay LE, Sicheri F, Dever TE. Requirement for kinase-induced conformational change in eukaryotic initiation factor 2α (eIF2α) restricts phosphorylation of Ser51. (2011) PNAS, 108, 4316-21.

Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D. Non-cononical inhibition of DNA damage-dependent ubiquitination by OTUB1.(2010) Nature, 466, 941-6.

Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M. An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. (2010) Nat Biotechnol, 28, 733-7.

Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. (2010) Mol Cell, 38, 291-304.

Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. A dimerization-dependent allosteric mechanism drives RAF catalytic activation. (2009) Nature, 461, 542-5.

Mittag T, Orlicky S, Choy W-Y, Tang X, Sicheri F, Kay LE, Tyers M, Forman-Kay JF. Dynamic equilibrium engagement of a polyvalent ligand with a single site receptor. (2008) Proc Natl Acad Sci, 105, 17772-7.

Mao DYL, Neculai D, Downey M, Orlicky S, Haffani Y, Ceccarelli DF, Ho JSL, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Durocher D, Sicheri F. Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. (2008) Molecular Cell, 32, 259-75.

Rajakulendran T, Sahmi M, Kourinov I, Tyers M, Therrien M, Sicheri F. CNK and HYP form a discrete dimer via their SAM domains to mediate RAF kinase signaling. (2008) Proc Natl Acad Sci, 105, 2836-41.

Kurz T, Chou Y-C, Willems A, Meyer-Schaller N, Hecht M-L, Tyers M, Peter M, Sicheri F. Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation (2008) Molecular Cell, 29, 23-35.

Lee K, Dey M, Neculai D, Cao C, Dever TE, Sicheri F. Structure of the Dual Enzyme Ire1 Reveals the Basis of Catalysis and Regulation in Nonconventional RNA Splicing. (2008) Cell, 132, 89-100.

Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain. (2007) Cell, 30, 651-62.

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli DF,  Mercurio F, Shilton BH, Sicheri F*, Tyers M. Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. (2007) Cell, 129, 1165-1176.

Wiesner S, Wybenga-Groot LE, Warner N, Lin H, Pawson T, Forman-Kay JD, Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. (2006) EMBO J., 25, 4686-4696.  

Aviv T, Lin Z, Ben-Ari G, Smibert CA, Sicheri F. Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p. (2006) Nat Struct Mol Biol, 13, 168-176.  

Dar AC, Dever TE, Sicheri F. Higher-order substrate recognition of eIF2α by the RNA-dependent protein kinase PKR. (2005) Cell, 122, 887-900.

Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE.  Mechanistic link between PKR dimerization, autophosphorylation, and eIF2α substrate recognition. (2005) Cell, 122, 901-913.

Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F*, Wrana JL. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. (2005). Mol Cell, 19, 297-308.

Hoang QQ, Sicheri F, Howard AJ, Yang DS. Bone recognition mechanism of porcine osteocalcin from crystal structure, (2003) Nature, 425, 977-980.

Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F*, Smibert CA. The RNA-binding SAM domain of smaug defines a new family of post-transcriptional regulators. (2003) Nat Struct Biol, 10, 614-621.

Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Structural basis for phosphodependent substrate selection and orientation by the SCF (Cdc4) ubiquitin ligase. (2003) Cell, 112, 243-256.

Leung GC, Hudson JW, Kozarova A, Davidson A, Dennis JW, Sicheri F.  The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. (2002) Nat Struct Biol,  9, 719-724.

Dar A, Sicheri, F. X-Ray Crystal Structure and Functional Analysis of Vaccinia Virus K3L Reveals Molecular Determinants for PKR Subversion and Substrate Recognition. (2002) Mol Cell, 10, 295-305.

Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M.  Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. (2001) Nature, 414, 514-521.

Wybenga-Groot LE, Baskin B, Pawson T, Sicheri F. Structural basis for autoinhibition of the EphB2 receptor tyrosinekinase by the unphosphorylated juxtamembrane region. (2001) Cell, 106, 745-757.

Schindler T, Sicheri F, Pico A, Gazit A, Levitzki A, Kuriyan J. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. (1999) Mol Cell, 3, 639-648.

Stapleton D, Balan I, Pawson T, Sicheri F. The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization. (1999) Nature Structural Biology, 1, 44-49.

Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. (1997) Nature, 385, 602-610.

Moarefi H, LaFevre-Bernt M, Sicheri F, Huse M, Lee C-H, Kuriyan J, Miller WT.  Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. (1997)  Nature, 385, 650-653.

Sicheri F, Yang, DS-C.  Ice binding structure and mechanism of an antifreeze protein from winter flounder. (1995) Nature, 375, 427-431.