Lily Guo, Scientific Associate
|
 |
|
I joined the Nagy Lab in 2018 as a postdoctoral fellow and currently serve as a Scientific Associate. My research focuses on aging as a primary risk factor for major chronic diseases and many forms of cancer.
Successful regeneration of aged tissue requires not only an appropriate therapeutic cell source to repair damage, but also the restoration of a youthful state within the aged cellular niche and extracellular matrix (ECM) to re-establish tissue homeostasis and function. Building on an established safe-cell system, we have designed and generated an optimized therapeutic cell source to target age-related diseases.
These “designer cells,” engineered with controlled proliferative capacity, can integrate into host tissues and contribute functionally to repair. At the same time, they act as a cellular “pump,” enabling drug-regulated delivery of precise doses of anti-aging molecules to rejuvenate local, age-compromised tissues.
This approach represents a promising avenue for cell-based therapies in age-related diseases. It is also broadly applicable as a platform for drug screening, advancing our understanding of the mechanisms underlying disease progression, and ultimately enabling the reversal of aging-associated phenotypes.
