Publications

305. Harding J, Vintersten-Nagy K, Yang H, Tang JK, Shutova M, Jong ED, Lee JH, Massumi M, Oussenko T, Izadifar Z, Zhang P, Rogers IM, Wheeler MB, Lye SJ, Sung HK, Li CJ, Izadifar M, Nagy A.  Immune-priviledged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts.  Nat Biomed Eng 2023. Nov 23. doi: 10.1038/s41551-023-01133-y.  PMID: 37996616

304.  Sawula E, Miersch S, Jong ED, Li CJ, Chou FY, Tang JK, Saberianfar R, Harding J, Sidhu SS, Nagy A.  Cell-based passive immunization for long-term protection against SARS-CoV-2 infection.  Stem Cell Res Ther 2023. Nov 6. 14(1): 318. doi: 10.1186/s13287-023-03556-5.  PMID: 37932852

303.  Izadifar M,Beresz T, Li B, Tang JKKY, Foldes G, Apati A, Nagy A.  Speckle-tracking strain analysis for mapping spatiotemporal contractility of induced-Pluripotent Stem Cell (iPSC)-derived cardiomyocittes.  Current Protocols in Pharmacology 2023, Sept 25; 3(9):e889. doi.org/10.1002/cpz1.889.  PMID: 3774746   

302.  Jong ED, Hacibekiroglu S, Guo L, Sawula E, Li B, Li CJ, HO MT,Shoichet M, Wallace VA, Nagy A.  Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa.  Stem Cell Res Ther 2023, Aug 21; 14(1): 212. doi: 10.1186/s13287-023-03434-0.  PMID 37605279

301. Elbaz J, Puri M, Faiz M, Bang A, Nguyen L, Makovoz B, Gertsenstein M, Hussein S, Zandstra PW, Briollais L, Shakiba N, Nagy A. Highly efficient reprogrammable mouse lines with integrated reporters to track the route to pluripotency. PNAS.  2022 December 1; 119(49): e2207824119. https://doi.org/10.1073/pnas.2207824119. PMID: 36454756

300. Varga BV, Faiz M, Pivonkova H, Khelifi G, Yang H, Gao S, Linderoth E, Zhen M, Karadottir RT, Hussein SM, Nagy A. Signal requirement for cortical potential of transplantable human neuroepithelial stem cells.  Nat Commun 2022 May 23; 13(1): 2844. doi: 10.1038/s41467-022-29839-8.  PMID: 35606347

299. Gawri R, Bielicki R, Salter EW, Zelinka A, Shiba T, Collingridge G, Nagy A, Kandel R. The anabolic effect of an organic polyphosphate on chondrocytes is mediated by calcium signaling.   J Orthop Res 2022 February. 40(2): 310-322.  PMID: 33719091

298.  Lyu D, Zhang LF,Qin ZW, Ni S, Li JY, Lu B, Hao SJ, Tanb QM, Yin H, Chen ZW, Yan YB, Ji JF, He J, Nagy A, Fu QL, Yao K.  Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells.  npj Regenerative Medicine 2021, Oct 1; 6(1): 60. doi: 10.1038/s41536-021-00171-x.  PMID: 34599192

297. Mesnieres M, Bohm AM, Pered N, Trompet D, Valle-Tenney R, Bajaj M, Corthout N, Nefyodova E, Cardoen R,Baatsen P, Munch S, Nagy A, Haigh JJ, Khurana S, Verfaillie CM, Maes C.  Fetal hematopoietic stem cell homing is controlled by VEGF regulating the intergrity and oxidative status of the stromal-vascular bone marrow niches.  Cell Rep 2021 Aug 24; 36(8): 109618. doi:10.1016/j.celrep.2021.109618. PMID: 34433017 

296. Wei Y, Wang T, Ma L, Zhang Y, Zhao Y, Lye K, Xiao L, Chen C, Wang Z, Ma Y, Zhoul X, Sun F, Li W, Dunk C, Li S, Nagy A, Yu Y, Pan G, Lye SJ, Shan Y.  Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells.  Sci Adv 2021 Aug 11  7(33):eabf4416. doi: 10.1126/sciadv.abf4416.  PMID: 334380613.

295. de Luzy IR, Law KC, Moriarty N, Hunt CP, Durnall JC, Thompson LH, Nagy A, Parish CL.  Human strem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats.  Nat Commun 2021, May 27; 12: 3275.  PMID: 34045451

294. Izadifar M, Berecz T, Apati A, Nagy A.  An optical-flow-based method to quantify dynamic behavior of human pluripotent stem cell-derived cardiomyocytes in disease modeling platforms.  Methods Mol Biol 2021 May 13. (epub ahead of print) doi: 10.1007/7651_2021_382.  PMID: 33982275.

293. Islam R, Drecun S, Varga BV, Vonderwalde I, Siiu R, Nagy A, Morshead CM.  Transplantation of human cortically-specified neuroepithelial progenitor cells leads to imporved functional outcomes in a mouse model of stroke.  Front Cell Neurosci 2021 Apr 29; 15: 654290.  PMID: 33994947

292. Covarrubias L, Martínez-Sarmiento JÁ, Valencia C, Nagy A, Hernández-García D. The levels of reprogramming factors influence the induction and maintenance of pluripotency: the case of CD1 mouse strain cells. Int J Dev Biol. 2021;65(4-5-6):365-376. doi:10.1387/ijdb.200233lc. PMID: 32930373

291. Varga BV, Faiz M, Yang H, Pivonkova H, Gao S, Khelifi G, Linderoth E, Zhen M, Husssein SM, Nagy A.  Signal requirement for cortical potential of transplantable human neuroepithelial stem cells.  bioRxiv doi: https://doi.org/10.1101/2021.03.27.437311

290. Gawri R, Bielicki R, Salter EW, Zelinka A, Shiba T, Collingridge G, Nagy A, Kandel R. (2021)  The anabolic effect of an organic polyphosphate on chondrocytes is mediated by calcium signaling.   J Orthop Res 2021 Mar 14.  doi: 10.1002/jor.25032.  PMID: 33719091

289. Abuwarwar MH, Baker AT, Harding J, Payne NL, Nagy A, Knoblich K, Fletcher AL.  (2021) In vitro suspension of T cell proliferation is a conserved function of primary and immortalized human cancer-associated fibroblasts. Inter J Mol Sci | Molec Immunol 2021 Feb 12; 22(4): 1827 doi: 10/3390/ijms22041827. PMID: 33672913

288. Mitrousis N, Hacibekiroglu S, Ho MT, Sauvé Y, Nagy A, van der Kooy D, Shoichet MS. (2020) Hydrogel-mediated co-transplantation or retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration.  Biomaterials  2020 Oct;257:120233. doi:10.1016/j.biomaterials.2020.120233. Epub 2020 Jul 30. PMID: 32791386

287. Harding J, Vinterstein-Nagy K, Nagy A.  (2020) Universal Stem Cells: making the unsafe safe.  Cell Stem Cell.  2020. Aug 6, 27(2): 198-9. Letter re: Gonzalez BJ et al, (Cell Stem Cell 26:307-308, March 5, 2020).  PMID: 32763181

286. Chow T, Wong F, Monetti C, Nagy A, Cox B, Rogers I. (2020)  Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers. NPJ Regen Med  2020.  April 20; 5:7 doi: 10.1038/s41536-020-0092-5. PMID: 32351711

285. Ross PJ, Zhang WB, Mok RSF, Zaslavsky K, Deneault E, D’Abate L, Rodrigues DC, Yuen RKC, Faheem M, Mufteey M, Piekna A, Wei W, Pasceri P, Landa RJ, Nagy A, Varga B, Salter MW, Scherer SW, Ellis J. (2020) Synaptic dysfunction in human neurons with autism-associated deletions in PTCHD1-AS. Biol Psychiatry 2020. Jan 15, 87(2): 139-149.  PMID:  31540669 

284. Araki R, Hoki Y, Suga T, Obara C, Sunayama M, Imadome K, Fujita M, Mamimura S, Nakamura M, Wakayama S, Nagy A, Wakayama T, Abe M.  (2020) Genetic aberrations in iPSC are introduced by a transient G1/S cell cycle checkpoint deficiency.  Nature Commun. 2020. Jan 10, 11(1): 197. PMID: 31934765

283. Wei R, Ren X, Kong H, Lv Z, Chen Y, Tank Y, Wang Y, Xiao L, Hacibekiroglu S, Liang C, Nagy A, Bremner R, Chen D. (2019) Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma. JCI | Insight. 2019 Nov 14; 4(22). doi: 10.1172/jci.insight.127889.  PMID: 31613797

282. Lanza R, Russell D, Nagy A.  (2019) Engineering universal cells that evade immune detection.  Nature Reviews | Immunology.  2019. Aug 15. doi: 10.1038/s41577-019-0200-1 [Epub head of print]. PMID: 31417198

281. Wong A, Shojaie S, Liang Q, Xia S, Di Paola M, Ahmadi S, Bilodeau C, Garner J, Post M, Duchesneau P, Waddell T, Bear C, Nagy A, Rossant J. (2019) Conversion of human and mouse fibroblasts into lung-like epithelial cells.  Nature | Scientific Report.  2019. Jun 21, 9(1):9027, doi: 10.1038/s41598-019-45195-y.  PMID: 31227724

280. Harding JS, Herbath M, Chen Y, Rayasam A, Ritter A, Csoka B, Hasko G, Michael IP, Fabry Z, Nagy A, Sandor M.  (2019) VEGF-A from granuloma macrophages regulates granulomatous inflammation by a non-angiogenic pathway during mycobacterial infection.  Cell Reports.  2019 May 14; 27(7): 2119-2131. PMID: 31091450

279. Nakanishi M, Mitchell RR, Benoit YD, Orlando L, Reid JC, Shimada K, Davidson KC, Shapovalova Z, Collins TJ, Nagy A, Bhatia M. (2019) Human pluripotency is initiated and preserved by a unique subset of founder cells.  Cell.  2019 May 2; 177(4):910-924.  PMID: 30982595

278. Shakiba N, Fahmy A, Jayakumaran G, McGibbon S, David L, Trcka D, Elbaz J, Puri MC, Nagy A, van der Kooy D, Goyal S, Wrana JL, Zandstra PW.  (2019) Competition during reprogramming gives rise to elite clones. Science. 2019 Mar 21. pii: eaan0925.doi:10.1126/ science.aan0925. [Epub ahead of print]. PMID: 30898844

277. Payne SL, Tuladhar A, Obermeyer JM, Varga BV, Teal CJ, Morshead CM, Nagy A, Shoichet MS. (2019) Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain.  Biomaterials 2019. Feb; 192:309-322.  PMID: 30468998

276. Wilhelmsson U, Lebkuechner I, Leke R, Marasek P, Yang X, Antfork D, Chen M, Mohseni P, Lasic E, Bobnar ST, Stenovec M, Zorec R, Nagy A, Sahlgren C, Pekna M, Pekny M. (2019) Nestin regulates neurogenesis in mice through notch signalling from astrocytes to neural stem cells.  Cereb Cortex.  2019 Jan 3; doi: 10.1093/cercor/bhy284 [epub ahead of print]. PMID: 30605503

275. Liang Q, Monetti C, Shutova MV, Neely EJ, Hacibekiroglu S, Yang H, Kim C, Zhang P, Li C, Nagy K, Mileikovsky M, Gyongy I, Sung HK, Nagy A. (2018)  Linking a cell-division gene and a suicide gene to define and improve cell therapy safety.   Nature. 2018.  Nov 21; 563(7733): 701-704 PMID: 30429614

274. Guo L, Karoubi G, Duchesneau P, Aoki FG, Shutova MV, Rogers I, Nagy A, Waddell TK. (2018) Interrupted reprogramming of alvelelolar type II cells induces progenitor-like cells that amelioiorate pulmonary fibrosis. NPJ Regen Med.. 2018 Sep 4;3:14. PMID: 30210809.

273.  Bogutz AB, Oh-McGinnis R, Jacob KJ, Ho-Lau R, Gu T, Gerstein M, Nagy A, Lefebvre L. (2018) Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage.  PLoS Genet. 2018. Aug 10; 14(8):e1007587 doi: 10.1371/journal.pgen.1007587 eCollection. PMID: 30096149.

272. Payne SL, Anandakumaran PN, Varga BV, Morshead CM, Nagy A, Shoichet MS.  (2018) In vitro maturation of human iPS-derived neuroepithelial cells influences transplant survival in the stroke-injured rat brain.  Tissue Eng Part A. 2018. Feb; 24(3-4):351-360.  PMID: 28594288

271. Führmann T, Anandakumaran P, Payne S, Pakulska M, Varga BV, Nagy A, Tator C, Shoichet MS. (2018)  Combined delivery of chondroitinase ABC and human induced pluripotent stem cell-derived neuroepithelial cells promote tissue repair in an animal model of spinal cord injury. Biomed Mater. 2018. Feb2; 13(2):024103. doi:10.1088/1748-605X/aa96dc.  PMID: 29083317

270. Guo L, Karoubi G, Duchesneau P, Shutova MV, Sung HK, Tonge P, Bear C, Rogers I, Nagy A, Waddell TK. (2017) Generation of Induced Progenitor-like Cells from Mature Epithelial Cells Using Interrupted Reprogramming. Stem Cell Reports. 2017 Dec 12;9(6):1780-1795. PMID: 29198829.

269. Kim KH, Kim YH, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Yoo JA, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SM, Doh KO, Hui CC, Sung HK. (2017). Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage.  Cell Res. 2017 Nov;27(11):1309-1326.  PMID: 29039412

268. Lindqvist J, Torvaldson E, Gullmets J, Karvonen H, Nagy A, Taimen P, Eriksson JE. (2017) Nestin contributes to skeletal muscle homeostasis and regeneration. J Cell Sci. 2017 Sep 1;130(17):2833-2842. PMID: 28733456

267. Andrews PW, Ben-David U, Benvenisty N, Coffey P, Eggan K, Knowles BB, Nagy A, Pera M, Reubinoff B, Rugg-Gunn PJ, Stacey GN. (2017) Assessing the safety of human pluripotent stem cells and their derivatives for clinical applications. Stem Cell Reports.  2017 Jul 11;9(1):1-4.  PMID: 28700896

266. Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, Koh GY.  (2017) VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. EMBO Mol Med. 2017 Jun;9(6):750-769. PMID: 28438786

265. Bertin E, Piccoli M, Franzin C, Nagy A, Mileikovskaia M, De Coppi P, Pozzobon M.  (2017) The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System. J Vis Exp. 2017 Feb 28;(120). PMID: 28287531

264. Massumi M, Pourasgari F, Nalla A, Batchuluun B, Nagy K, Neely E, Gull R, Nagy A,  Wheeler MB.  (2016) An Abbreviated Protocol for In Vitro Generation of Functional Human Embryonic Stem Cell-Dervied Beta-Like Cells.  PLoS One. 2016 Oct 18;11(10):e0164457. PMID: 27755557

263. Faiz M, Nagy A, Morshead CM.  (2016)  Response to: Where do you come from and what are you going to become, reactive astrocyte? Stem Cell Investig.  2016 Jul22;3:32.  PMID: 27582184

262. Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG. (2016) Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis. Cell. 2016 Feb 25;164(5):999-1014. PMID: 26875865

261. Bae YU, Choi JH, Nagy A, Sung HK, Kim JR.  (2016) Antisenescence effect of mouse embryonic stem cell conditioned medium through a PDGF/FGF pathway. FASEB J. 2016 Mar;30(3):1276-86. PMID: 26675707

260. Kim KH, Rosen A, Hussein SM, Puviindran V, Korogyi AS, Chiarello C, Nagy A, Hui CC, Backx PH.  (2016) Irx3 is required for postnatal maturation of the mouse ventricular conduction system.  Sci Rep. 2016 Jan 20;6:19197.  PMID: 26786475

259. Führmann T, Tam RY, Ballarin B, Coles B, Elliott Donaghue I, van der Kooy D, Nagy A, Tator CH, Morshead CM, Shoichet MS. (2016)  Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formaton in a spinal cord injury model.  Biomaterials.  2016 Mar;83:23-36. PMID: 26773663

258. Nagy, Andras; Turksen, Kursad (Eds.) (2016) Patient-Specific Induced Pluripotent Stem Cell Models. Generation and Characterization. Springer Protocls Methods in Molecular Biology 1353, Humana Press.

257. Turksen, Kursad; Nagy, Andras (Eds.) (2016) Induced Pluripotent Stem (iPS) Cells. Methods and Protocols.  Springer Protocols Methods in Molecular Biology 1357, Humana Press.

256. Lepage SI, Nagy K, Sung HK, Kandel R, Nagy A, Koch TG. (2016) Generation, characterization and multi-lineage potency of mesenchymal-like progenitors derived from equine induced pluripotent stem cells.  Stem Cells Dev. 2016 Jan 1;25(1):80-9. PMID: 26414480

255. Woltjen K, Kim SI, Nagy A. (2016) The piggyBac transposon as a platform technology for somatic cell reprogramming studies in mouse.  Method Mol Biol. 2016;1357:1-22. PMID: 26126450.

254. Nagy K, Nagy A. (2015) Derivation of Equine-Induced Pluripotent Stem Cell Lines Using a piggyBac Transposon Delivery System and Temporal Control of Transgene Expression.  Methods Mol Biol. 2015; 1330: Chapter 8 pages 79-88. PMID: 26621591

253. Faiz M, Sachewsky N, Gascón S, Bang KW, Morshead CM, Nagy A. (2015) Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke. Cell Stem Cell.  2015 Nov 5;17(5):624-34. PMID: 26456685

252. Bertin E, Piccoli M, Franzin C, Nagy A, Mileikovsky M, De Coppi P, Pozzobon M. (2015)  Reprogramming of mouse amniotic fluid cells using a PiggyBac transposon system. Stem Cell Research, November 2015, 15(3): 510-513.  PMID: 26987920

251.  Furio L, Pampalakis G, Michael IP, Nagy A, Sotiropoulou G, Hovnanian A. KLK5 (2015) Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome.  PLoS Genet. 2015 Sep 21;11(9):e1005389. PMID: 26390218

250. Benevento M, Tonge PD, Puri MC, Nagy A, Heck AJ, Munoz J. (2015)  Fluctuations in hisone H4 isoforms during cellular reprogramming monitored by middle-down proteomics. Proteomics.  2015 Sep;15(18):3219-31. PMID: 26080932

249. Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SM, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munox J, Benevento M, Rogers IM, Hanna JH, Heck AJ, Wollscheid B, Nagy A, Zandstra PW. (2015) CD24 tracks divergent pluripotent states in mouse and human cells. Nat Commun. 2015 Jun 16;6:7329.  PMID: 26076835

248. Cunnigham SC, Siew SM, Hallwirth CV, Bolitho C, Sasaki N, Garg G, Michael IP, Hetherington NA, Carpenter K, de Alencastro G, Nagy A, Alexander IE. (2015) Modeling correction of severe urea cycle defects in the growing murine liver using a hybird recombinant adeno-associated virus/piggyBac tranposase gene delivery system.  Hepatology. 2015 Aug;62(2):417-28. PMID: 26011400.

247. Salewski RP, Mitchell RA, Li L, Shen C, Milekovskaia M, Nagy A, Fehlings MG. (2015) Transplantation of Induced Pluripotent Stem Cell-Derived Neural Stem Cells Mediate Functional Recovery Following Thoracic Spinal Cord Injury Through Remyelination of Axons.  Stem Cells Transl Med. 2015 Jul;4(7):743-54. PMID: 25979861.

246.  Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, Desai R, Nagy A, Niswander L, Moss EG, Chen JF. (2015)  Lin28 promotes the proliferative capacity of neural progenitor cells in brain development.  Development.  2015 May 1; 142(9):1616-27.  PMID: 25922525.

245. Madisen L, Garner AR, Shimaoka D, Chuong AS, Klapoetke NC, Li L, van der Bourg A, Niino Y, Egolf L, Monetti C, Gu H, Mills M, Cheng A, Tasic B, Nguyen TN, Sunkin SM, Benucci A, Nagy A, Miyawaki A, Helmchen F, Empson RM, Knöpfel T, Boyden ES, Reid RC, Carandini M, Zeng H.  (2015) Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance. Neuron. 2015 Mar 4;85(5):942-58. PMID: 25741722.

244. Andrews P, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi YM, Crook J, de Sousa P, Dvorak P, Freund C, Firpo M, Furue M, Gokhale P, Ha HY, Han E, Haupt S, Healy L, Hei Dj, Hovatta O, Hunt C, Hwang SM, Inamdar M, Isasi R, Jaconi M, Jekerle V, Kamthorn P, Kibbey M, Knezevic I, Knowles B, Koo SK, Laabi Y, Leopoldo L, Liu P, Lomax G, Loring J, Ludwig T, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh SK, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala K, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey G, Suemori H, Takahashi T, Takada K, Talib S, Tannenbaum S, Yuan BZ, Zeng F, Zhou Q. (2015) Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI). Regen Med. 2015;10(2 Suppl):1-44. PMID: 25675265

243. Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Lê Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A.  (2014) Genome-wide characterization of the routes to pluripotency. Nature. 2014 Dec 11;516(7530):198-206. PMID: 25503233

242. Tonge PD, Corso AJ, Monetti C, Hussein SM, Puri MC, Michael IP, Li M, Lee DS, Mar JC, Cloonan N, Wood DL, Gauthier ME, Korn O, Clancy JL, Preiss T, Grimmond SM, Shin JY, Seo JS, Wells CA, Rogers IM, Nagy A. (2014)  Divergent reprogramming routes lead to alternative stem-cell states. Nature. 2014 Dec 11;516(7530):192-7. PMID: 25503232

241. Benevento M, Tonge PD, Puri MC, Hussein SM, Cloonan N, Wood DL, Grimmond SM, Nagy A, Munoz J, Heck AJ.  (2014) Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks. Nat Commun. 2014 Dec 10;5:5613. PMID: 25794451  

240. Clancy JL, Patel HR, Hussein SM, Tonge PD, Cloonan N, Corso AJ, Li M, Lee DS, Shin JY, Wong JJ, Bailey CG, Benevento M, Munoz J, Chuah A, Wood D, Rasko JE, Heck AJ, Grimmond SM, Rogers IM, Seo JS, Wells CA, Puri MC, Nagy A, Preiss T.  (2014) Small RNA changes en-route to distinct cellular states of induced pluripotency. Nat Commun. 2014 Dec 10;5:5522.  PMID: 25494340

239. Lee DS, Shin JY, Tonge PD, Puri MC, Lee S, Park H, Lee WC, Hussein SM, Bleazard T, Yun JY, Kim J, Li M, Cloonan N, Wood D, Clancy JL, Mosbergen R, Yi JH, Yang KS, Kim H, Rhee H, Wells CA, Preiss T, Grimmond SM, Rogers IM, Nagy A, Seo JS. (2014)  An epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator. Nat Commun. 2014 Dec 10;5:5619.  PMID: 25493341

238. Li H, Qu D, McDonald A, Isaac SM, Whiteley KJ, Sung HK, Nagy Aand Adamson SL.  (2014) Trophoblast-Specific Reduction of VEGFA Alters Placental Gene Expression and Maternal Cardiovascular Function in Mice. Biol Reprod. 2014 Oct;91(4):87. PMID: 25122061

237. Martinez-Fernandez A, Nelson TJ, Reyes S, Alekseev AE, Secreto F, Perez-Terzic C, Beraldi R, Sung HK, Nagy A,Terzic A. (2014)  iPS Cell-Derived Cardiogenicity is Hindered bySustained Integration of Reprogramming Transgenes. Circ Cardiovasc Genet. 2014 Oct;7(5):667-76.  PMID: 25077947 

236. Onishi K, Tonge PD, Nagy A, Zandstra P. (2014) Local BMP-SMAD1 signaling increases LIF receptor-dependent STAT3 responsiveness and primed-to-naive mouse pluripotent stem cell conversion frequency.  Stem Cell Reports. 2014 Jun 6;3(1):156-68. PMID: 24244203

235. Michael IP, Westenskow PD, Hacibekiroglu S, Cohen Greenwald A, Ballios BG, Kurihara T, Li Z, Warren CM, Zhang P, Aguilar E, Donaldson L, Marchetti V, Baba T, Hussein SM, Sung HK, Iruela-Arispe ML, Rini JM, van der Kooy D, Friedlander M, Nagy A.  (2014)  Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med. 2014 May 1;6(5):604-23.  PMID: 24705878.   

234. Harris MG, Hulseberg P, Ling C, Karman J, Clarkson BD, Harding JS, Zhang M, Sandor A, Christensen K, Nagy A, Sandor M, Fabry Z. (2014)  Immune privilege of the CNS is not the consequence of limited antigen sampling. Sci Rep.  2014 Mar 21;4:4422. PMID: 24651727

233. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ,Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH,Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S,Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC,Gomez-Skarmeta JL, Nóbrega MA. (2014)  Obesity-associated variants withinFTO form long-range functional connections with IRX3.  Nature. 2014. Mar 20;507(7492):371-5. PMID: 24646999

232. Behringer R., Gertsenstein M., Vintersten K. and Nagy A. (2014) Manipulating the Mouse Embryo: A Laboratory manual. 4rd edition, Cold Spring Harbor Press, Cold Spring Harbor, New York

231. Huang K, Shen Y, Xue Z, Bibikova M, April C, Liu Z, Cheng L, Nagy A, Pellegrini M, Fan JB, Fan G. (2013) A Panel of CpG Methylation Sites Distinguishes Human Embryonic Stem cells and Induced Pluripotent Stem Cells. Stem Cell Reports.  2013.  Dec 26; 2(1): 36-43. PMID: 24511466

230. Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. (2013) Distinct Functions for Wnt/β-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis. Cell Stem Cell.  2013. Dec 5;13(6):720-33. doi: 10.1016/j.stem.2013.10.003. PMID: 24315444

229. DeVeale B, Brokhman I, Mohseni P, Babak T, Yoon C, Lin A, Onishi K, Tomilin A, Pevny L, Zandstra PW, Nagy A, van der Kooy D. (2013) Oct4 Is Required ∼E7.5 for Proliferation in the Primitive Streak. PLoS Genetics.  2013. Nov; 9(11):e1003957; doi: 10.1371/journal.pgen.1003957.  PMID: 24244203

228. Westenskow PD, Kurihara T, Aguilar E, Scheppke EL, Moreno SK, Wittgrove C, Marchetti V, Michael IP, Anand S, Nagy A, Cheresh D, Friedlander M. (2013) Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting. J Clin Invest. 2013. Nov; 123(11): 4900-4908.  PMID: 24084735

227. Nagy A. (2013) Secondary cell reprogramming systems, as the years go by.  Curr Opin Genet Dev.  2013. Oct; 23(5): 534-539.  PMID: 23968685

226. Muñoz DM, Singh S, Tung T, Agnihotri S, Nagy A, Guha A, Zadeh G, Hawkins C. (2013) Differential transformation capacity of neuro-glial progenitors during development. Proc Natl Acad Sci U S A 2013. Aug 27; 110(35): 14378-83.  PMID: 23942126

225. Kim M, Ju Park H, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. (2013) VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodeling during pregnancy.  EMBO Mol Med  2013. Sept; 5(9): 1415-30.  PMID: 23853117

224. Faiz M and Nagy A, (2013) Induced Pluripotent Stem Cells and Disorders of the Nervous System: Progress, Problems, and Prospects. Neuroscientist. 2013 Jun 24. [Epub ahead of print]

223. Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, Barbosa-Morais NL, Burge CB, Moffat J, Frey BJ, Nagy A, Ellis J, Wrana JL, Blencowe BJ.(2013) MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature. 2013 Jun 5. doi: 10.1038/nature12270. [Epub ahead of print]

222. Li Z, Michael IP, Zhou D, Nagy A, Rini JM. (2013) Simple piggyBac transposon-based mammalian cell expression system for inducible protein production. Proc Natl Acad Sci U S A. 2013 Mar 8.

221. Lieven Haenebalcke, Steven Goossens, PieterjanDierickx, Sonia Bartunkova, Jinke D’Hont, Katharina Haigh, TinoHochepied, Dagmar Wirth, Andras Nagy, Jody J. Haigh (2013) The ROSA26-iPSC Mouse: A Conditional, Inducible, and Exchangeable Resource for Studying Cellular (De)Differentiation. Cell Reports, 07 February 2013

220. Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SML, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson A, Nagy A. (2013) Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis. Cell Metabolism. Volume 17, Issue 1, 61-72, 8 January 2013

219. Michael IP, Monetti C, Chiu AC, Zhang P, Baba T, Nishino K, Agha-Mohammadi S, Woltjen K, Sung HK, Nagy A. (2012) Highly efficient site-specific transgenesis in cancer cell lines.  Mol Cancer. 2012 Dec 11;11(1):89. [Epub ahead of print]

218. Hussein SM, Elbaz J, Nagy A (2012) Genome damage in induced pluripotent stem cells: Assessing the mechanisms and their consequences. Bioessays. 2012 Nov 22. doi: 10.1002/bies.201200114. [Epub ahead of print]

217. Jin J, Sison K, Li C, Tian R, Wnuk M, Sung HK,Jeansson M, Zhang C, Tucholska M, Jones N, Kerjaschki D, Shibuya M,Fantus IG, Nagy A, Gerber HP, Ferrara N, Pawson T, Quaggin SE. (21012) Soluble FLT1 Binds Lipid Microdomains in Podocytes to Control Cell Morphology and Glomerular Barrier Function. Cell. 2012 Oct 12;151(2):384-99. doi: 10.1016/j.cell.2012.08.037.

216. Lee YL, Peng Q, Fong SW, Chen AC, Lee KF, Ng EH, Nagy A,Yeung WS. (2012) Sirtuin 1 Facilitates Generation of InducedPluripotent Stem Cells from Mouse Embryonic Fibroblasts through themiR-34a and p53 Pathways. PLoS One. 2012;7(9):e45633. doi: 10.1371/journal.pone.0045633. Epub 2012 Sep 21.

215. Onishi K, Tonge PD, Nagy A, Zandstra PW.(2012) Microenvironment-mediated reversion of epiblast stem cells by reactivation of repressed JAK-STAT signaling. Integr Biol (Camb). 2012 Sep 18. [Epub ahead of print]

214. Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C,Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W,Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH,Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J,Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M,Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K,Koutsourakis M, Kent Lloyd KC, Marschall S, Mason J, McKerlie C, McLeodMP, von Melchner H, Moore M, Mujica AO, Nagy A, NefedovM, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R,Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N,Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, SchofieldP, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D,Stanford WL, Francis Stewart A, Stone K, Swan K, Tadepally H, Teboul L,Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura KI, Yoshinaga Y,Wurst W. (2012) The mammalian gene function resource: the international knockout mouse consortium. Mamm Genome. 2012 Sep 12. [Epub ahead of print]

213. Hussein SM, Nagy A. (2012) Progress made in the reprogramming field: new factors, new strategies and a new outlook. Curr Opin Genet Dev. 2012 Sep 5. [Epub ahead of print]

212. Salewski RP, Buttigieg J, Mitchell RA, van der Kooy D, Nagy A, Fehlings MG.(2012) The generation of definitive neural stem cells from piggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signalling pathway. Stem Cells Dev. 2012 Aug 13. [Epub ahead of print]

211. Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming SA.(2012) CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood. 2012 May 10. PMID: 22577176[Epub ahead of print]

210. Fluri DA, Tonge PD, Song H, Baptista RP, Shakiba N, Shukla S, Clarke G, Nagy A, Zandstra PW. (2012) Derivation, expansion and differentiation of induced pluripotent stem cells in continuous suspension cultures. Nat Methods. 2012 Mar 25.

209. Teta M, Choi YS, Okegbe T, Wong G, Tam OH, Chong MM, Seykora JT, Nagy A, Littman DR, Andl T, Millar SE. (2012) Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development. 2012 Apr;139(8):1405-16.

208. Ji J, Ng SH, Sharma V, Neculai D, Hussein S, Sam M, Trinh Q, Church GM, McPherson JD, Nagy A, Batada NN. (2011) Elevated Coding Mutation Rate During the Reprogramming of Human Somatic Cells into Induced Pluripotent Stem Cells. Stem Cells. 2011 Dec 12. doi: 10.1002/stem.1011. [Epub ahead of print]

207. The International Stem Cell Initiative, Amps K,Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J,Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC,Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E,Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, DeSousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A,Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H,Gropp M, Guangxiu L, Hampl A, Harron K, Healy L, Herath W, Holm F,Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y,Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A,Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, LiC, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, MileikovskyM, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A,Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, ParkIH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A,Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Mohamed JS, ShenH, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN,Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K,Tuuri T, Venu P, Verlinsky Y, Oostwaard DW, Weisenberger DJ, Wu Y,Yamanaka S, Young L, Zhou Q. (2011) Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol. 2011 Nov 27. doi: 10.1038/nbt.2051. [Epub ahead of print]

206. Puri MC, Nagy A. (2011) Concise Review: ES vs. iPS Cells; the Game is on. Stem Cells. 2011 Nov 18. doi: 10.1002/stem.788. [Epub ahead of print]

205. Mathieu Gabut, Payman Samavarchi-Tehrani, XinchenWang, Valentina Slobodeniuc, Dave O'Hanlon, Hoon-Ki Sung, ManuelAlvarez, Shaheynoor Talukder, Qun Pan, Esteban O. Mazzoni, StephaneNedelec, Hynek Wichterle, Knut Woltjen, Timothy R. Hughes, Peter W.Zandstra, Andras Nagy, Jeffrey L. Wrana, Benjamin J. Blencowe (2011) An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming. Cell, 15 September 2011

204. Woltjen K, Hämäläinen R, Kibschull M, Mileikovsky M, Nagy A. (2011) Transgene-Free Production of Pluripotent Stem Cells Using piggyBac Transposons. Methods Mol Biol. 2011;767:87-103.

203. Mohseni P, Sung HK, Murphy AJ, Laliberte CL, Pallari HM, Henkelman M, Georgiou J, Xie G, Quaggin SE, Thorner PS, Eriksson JE and Nagy A. (2011) Nestinis not essential for development of the central nervous system butrequired for dispersion of acetylcholine receptor clusters at the areaof neuromuscular junctions. J Neurosci. 2011 Aug 10;31(32):11547-11552.

202. Nishino K, Hattori N, Sato S, Arai Y, Tanaka S, Nagy A, Shiota K. (2011) Non-CpG Methylation Occurs in the Regulatory Region of the Sry Gene. J Reprod Dev. 2011 Jun 3. [Epub ahead of print]

201. Adachi H, Kondo T, Koh GY, Nagy A, Oike Y, Araki E. (2011) Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice. Biochem Biophys Res Commun. 2011 Apr 28. [Epub ahead of print]

200. Hussein SM, Nagy K, Nagy A. (2011) Human Induced Pluripotent Stem Cells: The Past, Present, and Future, Clinical Pharmacology & Therapeutics , (23 March 2011) | doi:10.1038/clpt.2011.37

199. Hussein SM, BatadaNN, Vuoristo S, Ching RW, Autio R, Närvä E, Ng S, Sourour M, HämäläinenR, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O,Bazett-Jones DP, Alitalo K, Lahesma R, Otonkoski T. Nagy A (2011) Copy number variation and selection during reprogramming to pluripotency. Nature. 2011 Mar 3;471(7336):58-62.

198. Nagy K, Sung HK, Zhang P, Laflamme S, Vincent P, Agha-Mohammadi S,Woltjen K, Monetti C, Michael IP, Smith LC, Nagy A. (2011) Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts. Stem Cell Rev. 2011 Feb 24. [Epub ahead of print]Erratum to: Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts.

197. Huang G, Ge G, Wang D, Gopalakrishnan B, Rutz DH, Colman RJ, Nagy A, Greenspan DS.  (2011) α3(V) Collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues. J. Clin. Invest  2011. Feb; 121(2): 769-83.  PMID: 21293061

196. Monetti C, Nishino K, Biechele S, Zhang P, Baba T, Woltjen K, Nagy A. (2010) PhiC31 integrase facilitates genetic approaches combining multiple recombinases. Methods. 2010 Dec 22. [Epub ahead of print]

195. Hardouin SN, Guo R, Romeo PH, Nagy A, Aubin JE. (2010) Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. Development. 2010 Dec 9. [Epub ahead of print]

194. Tonge PD, Nagy A. (2010) Extinction of Xist improves cloning. Cell Stem Cell. 2010 Nov 5;7(5):550-2.

193. Kibschull M, Mileikovsky M, Michael IP, Lye SJ, Nagy A. (2010) Human embryonic fibroblasts support single cell enzymatic expansion of human embryonic stem cells in xeno-free cultures. Stem Cell Res. 2010 Aug 27. [Epub ahead of print]

192. Koh YJ, Kim HZ, Hwang SI, Lee JE, Oh N, Jung K, Kim M, Kim KE, Kim H, Lim NK, Jeon CJ, Lee GM, Jeon BH, Nam DH, Sung HK, Nagy A, Yoo OJ, KohGY. (2010) Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage. Cancer Cell. 2010 Aug 9;18(2):171-184.

191. Nagy A, Nagy K, Gertsenstein M. (2010) Production of mouse chimeras by aggregating pluripotent stem cells with embryos. Methods Enzymol. 2010;476:123-49.

190. Gertsenstein M, Nutter LM, Reid T, Pereira M, Stanford WL, Rossant J, Nagy A. (2010) Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos. PLoS One. 2010 Jun 22;5(6):e11260.

189. Drogat B, Kalucka J, Gutiérrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmüller U, Lambrecht B, Nagy A, Philipsen S, Haigh JJ.(2010) VEGF regulates embryonic erythroid development through GATA1 modulation. Blood. 2010 Jun 16. [Epub ahead of print]

188. Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL (2010) Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming. Cell Stem Cell. 2010 Jul 2;7(1):64-77. Epub 2010 Jun 17.

187. Nagy A, Quaggin SE. (2010) Stem Cell Therapy for the Kidney: A Cautionary Tale. J Am Soc Nephrol. 2010 Jun 17. [Epub ahead of print]

186. Liu F, Dangaria S, Andl T, Zhang Y, Wright AC, Damek-Poprawa M, PiccoloS, Nagy A, Taketo M, Diekwisch TG, Akintoye SO, Millar SE. (2010) {beta}-catenin Initiates Tooth Neogenesis in Adult Rodent Incisors. J Dent Res.  2010. Sept; 89(9): 909-914.  PMID: 20530729

185. Tardif S, Wilson MD, Wagner R, Hunt P, Gertsenstein M, Nagy A, Lobe C, Koop BF, Hardy DM. (2010) Zonadhesin is essential for species specificity of sperm adhesion to the egg's zona pellucida. J Biol Chem. 2010 Jun 7. [Epub ahead of print]

184.Hai B, Yang Z, Millar SE, Choi YS, Taketo MM, Nagy A, Liu F. (2010)Wnt/beta-catenin signaling regulates postnatal development andregeneration of the salivary gland. Stem Cells Dev. 2010 Mar 30. [Epub ahead of print]

183. Coultas L, Nieuwenhuis E, Anderson GA, Cabezas J, Nagy A, Henkelman RM, Hui CC, Rossant J. (2010) Hedgehog regulates distinct vascular patterning events through VEGF dependent and independent mechanisms. Blood. 2010 Mar 25. [Epub ahead of print]

182. Sung HK, Michael IP, Nagy A. (2010) Multifacetedrole of vascular endothelial growth factor signaling in adult tissuephysiology: an emerging concept with clinical implications. Curr Opin Hematol. 2010 Mar 4. [Epub ahead of print] PMID: 20216210 [PubMed - as supplied by publisher]

181. Vecchiarelli-Federico LM, Cervi D, Haeri M, Li Y, Nagy A, Ben-David Y. (2010) Vascular endothelial growth factor--a positive and negative regulator of tumor growth. Cancer Res. 2010 Feb 1;70(3):863-7. Epub 2010 Jan 26.

180. Yamanaka N, Wong CJ, Gertsenstein M, Casper RF, Nagy A, Rogers IM. (2009) Bonemarrow transplantation results in human donor blood cells acquiring anddisplaying mouse recipient class I MHC and CD45 antigens on theirsurface. PLoS One. 2009 Dec 31;4(12):e8489.

179. Nagy A, Nagy K (2009) The mystery of induced pluripotency: where will they lead? Nature Methods. [Epub ahead of print] - Commentary, Special feature

178.Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, StockmansI, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, TuckermannJP, Tjwa M, Carmeliet P, Mandic V, David JP, Behrens A, Nagy A,Carmeliet G, Haigh JJ. (2009) Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J.. [Epub ahead of print]

177. Ahmed N, Taylor DW, Wunder J, Nagy A, Gross AE, Kandel RA. J (2009) Passaged human chondrocytes accumulate extracellular matrix when induced by bovine chondrocytes. Tissue Eng Regen Med. 2009 Dec 8. [Epub ahead of print]

176.Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L,Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC,Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE. (2009) Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L45-56. Epub 2009 Nov 6.

175. Giuffrida D, Rogers IM, Nagy A, Calogero AE, Brown TJ, Casper RF. (2009) Human embryonic stem cells secrete soluble factors that inhibit cancer cell growth. Cell Prolif. 2009 Sep 1. [Epub ahead of print]

174.Louis Lefebvre; Lynn Mar; Aaron Bogutz; Rosemary Oh-McGinnis; MohammadMandegar; Jana Paderova; Marina Gertsenstein; Jeremy A. Squire; AndrasNagy (2009) The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region. Human Molecular Genetics 2009; doi: 10.1093/hmg/ddp379

173. Godmann M, Gashaw I, Katz JP, Nagy A, Kaestner KH, Behr R. (2009) Krüppel-likefactor 4, a "pluripotency transcription factor" highly expressed inmale postmeiotic germ cells, is dispensable for spermatogenesis in themouse. Mech Dev. 2009 Jun 17. [Epub ahead of print]

172. Ivics Z, Li MA, Mátés L, Boeke JD, Nagy A, Bradley A, Izsvák Z. (2009) Transposon-mediated genome manipulation in vertebrates. Nat Methods. 2009 Jun;6(6):415-22.

171.Nyabi O, Naessens M, Haigh K, Gembarska A, Goossens S, Maetens M, DeClercq S, Drogat B, Haenebalcke L, Bartunkova S, De Vos I, De Craene B,Karimi M, Berx G, Nagy A, Hilson P, Marine JC, Haigh JJ. (2009) Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells. Nucleic Acids Res. 2009 Mar 11. [Epub ahead of print]

170. Tanaka M, Hadjantonakis AK, Vintersten K, Nagy (2009) Aggregation Chimeras: Combining ES Cells, Diploid, and Tetraploid Embryos. A. Methods Mol Biol. 2009;530:1-23.

169. Nagy A, Mar L, Watts G.(2009) Creation and use of a cre recombinase transgenic database. Methods Mol Biol. 2009;530:1-14.

168. Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. (2009) Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell. 2009 Mar 6;4(3):198-9; author reply 202. No abstract available.

167. WoltjenK, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, CowlingR, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A. (2009) piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009 Mar 1. [Epub ahead of print]

166. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 2009 Mar 1. [Epub ahead of print]

165. AdachiH, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N,Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K,Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A,Suda T, Oike Y, Araki E. (2008) Angptl 4 deficiency improves lipidmetabolism, suppresses foam cell formation and protects againstatherosclerosis. Biochem Biophys Res Commun. 2008 Dec 16. [Epub ahead of print]

164.Hadjantonakis AK, Pirity M, Nagy A. (2008) Cre recombinase mediatedalterations of the mouse genome using embryonic stem cells. Methods Mol Biol. 2008;461:111-32. Review. No abstract available.

163. AhmedN, Gan L, Nagy A, Zheng J, Wang C, Kandel RA. (2008) Cartilage TissueFormation Using Redifferentiated Passaged Chondrocytes In Vitro. Tissue Eng Part A. 2008 Sep 10. [Epub ahead of print]

162. PurpuraKA, George SH, Dang SM, Choi K, Nagy A, Zandstra PW. (2008) SolubleFlt-1 regulates Flk-1 activation to control hematopoietic andendothelial development in an oxygen-responsive manner. Stem Cells. 2008 Nov;26(11):2832-42. Epub 2008 Sep 4.

161. SéguinCA, Draper JS, Nagy A, Rossant J. (2008) Establishment of endodermprogenitors by SOX transcription factor expression in human embryonicstem cells. Cell Stem Cell. 2008 Aug 7;3(2):182-95.

160. ZhangY, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S,Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE.(2008)Activation of beta-catenin signaling programs embryonic epidermis tohair follicle fate. Development. 2008 Jun;135(12):2161-72. Epub 2008 May 14.

159. AlbertiK, Davey RE, Onishi K, George S, Salchert K, Seib FP, Bornhäuser M,Pompe T, Nagy A, Werner C, Zandstra PW. (2008) Functional immobilizationof signaling proteins enables control of stem cell fate. Nat Methods. 2008 Jun 15.

158.Cohen CB, Brandhorst B, Nagy A, Leader A, Dickens B, Isasi RM, Evans D,Knoppers BM. (2008) The use of fresh embryos in stem cell research:ethical and policy issues. Cell Stem Cell. 2008 May 8;2(5):416-21.

157.O'Connor MD, Kardel MD, Iosfina I, Youssef D, Lu M, Li MM, VercauterenS, Nagy A, Eaves CJ. (2008) Alkaline Phosphatase-positive ColonyFormation is a Sensitive, Specific and Quantitative Indicator ofUndifferentiated Human Embryonic Stem Cells. Stem Cells. 2008 Feb 14; [Epub ahead of print] PMID: 18276800

156.Kolodziejska KM, Ashraf HN, Nagy A, Bacon A, Frampton J, Xin HB,Kotlikoff MI, Husain M. (2008) c-Myb Dependent Smooth Muscle CellDifferentiation. Circ Res. 2008 Jan 10; [Epub ahead of print] PMID: 18187733

155.Wilson MD, Wang D, Wagner R, Breyssens H, Gertsenstein M, Lobe C, Lu X,Nagy A, Burke RD, Koop BF, Howard PL. (2007) Ars2 is a conservedeukaryotic gene essential for early mammalian development. Mol Cell Biol. 2007 Dec 17; [Epub ahead of print]

154.Oh R, Ho R, Mar L, Gertsenstein M, Paderova J, Hsien J, Squire JA,Higgins MJ, Nagy A, Lefebvre L. (2007) Epigenetic and phenotypicconsequences of a truncation disrupting the imprinted domain on distalmouse chromosome 7. Mol Cell Biol. 2007 Nov 26; [Epub ahead of print]

153.Peerani R, Rao BM, Bauwens C, Yin T, Wood GA, Nagy A, Kumacheva E,Zandstra PW. (2007) Niche-mediated control of human embryonic stem cellself-renewal and differentiation.EMBO J. 2007 Oct 18; [Epub ahead of print]

152.MacAulay K, Doble BW, Patel S, Hansotia T, Sinclair EM, Drucker DJ,Nagy A, Woodgett JR. (2007) Glycogen synthase kinase 3alpha-specificregulation of murine hepatic glycogen metabolism. Cell Metab. 2007 Oct;6(4):329-37.

151.Sunyoung Lee, Tom T. Chen, Chad L. Barber, Maria C. Jordan, JaredMurdock, Sharina Desai, Napoleone Ferrara, Andras Nagy, Kenneth P. Roos,and M. Luisa Iruela-Arispe (2007) Autocrine VEGF Signaling Is Required for Vascular Homeostasis. Cell, Vol 130, 691-703.

150.The International Stem Cell Initiative*, Adewumi O, Aflatoonian B,Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, BenvenistyN, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, ChurchillGA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA,Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A,Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J,Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F,Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M,Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N,O'brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H,Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE,Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, SiemenH, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, TuuriT, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, YoungLA, Zhang W. (2007) Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol. 2007 Jun 17; [Epub ahead of print] PMID: 17572666 [PubMed - as supplied by publisher]

149.Sophia H. L. George, Marina Gertsenstein, Kristina Vintersten, EllaKorets-Smith, John Murphy, Mary E. Stevens, Jody J. Haigh, and AndrasNagy (2007) Developmental and adult phenotyping directly from mutant embryonic stem cells. PNAS published March 2, 2007, 10.1073/pnas.0609277104

148. Cervi D, Shaked Y, Haeri M, Usenko T, Lee CR, Haigh JJ, Nagy A, Kerbel RS, Yefenof E, Ben-David Y. (2007) Enhanced natural-killer cell and erythropoietic activities in VEGF-A-overexpressing mice delay F-MuLV-induced erythroleukemia. Blood. 2007 Mar 1;109(5):2139-46. Epub 2006 Oct 19

147. The International Mouse Knockout Consortium (2007) A mouse for all reason. Cell128, January 12, 2007: 9-13.

146. Draper JS, Nagy A. (2006) Improved embryonic stem cell technologies. Handb Exp Pharmacol. 2007;178:107-28. PMID: 17203653

145. Nagy A, Vintersten K. (2006) Murine embryonic stem cells. Methods Enzymol. 2006;418:3-21. PMID: 17141026

144. Takeda K, Ho V, Takeda H, Duan LJ, Nagy A, Fong GH. (2006) Placentalbut not Heart Defect Is Associated with Elevated HIF{alpha} Levels inMice Lacking Prolyl Hydroxylase Domain Protein 2. Mol Cell Biol. 2006 Sep 11; [Epub ahead of print]

143. Amano T, Gertsenstein M, Nagy A, Kurihara H, Suzuki H. (2006) Nucleartransfer reprogramming does not improve the low developmental potencyof embryonic stem cells induced by long-term culture. Reproduction. 2006 Aug;132(2):257-63.

142. Wada T, Haigh JJ, Ema M, Hitoshi S, Chaddah R, Rossant J, Nagy A, van der Kooy D. (2006) Vascularendothelial growth factor directly inhibits primitive neural stem cellsurvival but promotes definitive neural stem cell survival. J Neurosci. 2006 Jun 21;26(25):6803-12.

141. Eremina V, Cui S, Gerber H, Ferrara N, Haigh J, Nagy A, Ema M, Rossant J, Jothy S, Miner JH, Quaggin SE. (2006) Vascularendothelial growth factor a signaling in the podocyte-endothelialcompartment is required for mesangial cell migration and survival. J Am Soc Nephrol. 2006 Mar;17(3):724-35. Epub 2006 Jan 25.

140. Nagy A. (2005) Following Ariadne's thread in the labyrinth of mouse phenotypes. Development. 2005 Dec;132(23):5130-2.

139.Chen J, Reifsnyder PC, Scheuplein F, Schott WH, Mileikovsky M,Soodeen-Karamath S, Nagy A, Dosch MH, Ellis J, Koch-Nolte F, Leiter EH.(2005) "Agouti NOD": identification of a CBA-derived Idd locuson Chromosome 7 and its use for chimera production with NOD embryonicstem cells. Mamm Genome. 2005 Oct;16(10):775-783. Epub 2005 Oct 29.

138. Bubnic SJ, Nagy A, Keating A. (2005) Donor hematopoietic cells from transgenic mice that express GFP are immunogenic in immunocompetent recipients. Hematology. 2005 Aug;10(4):289-95.

137. Schnabel D, Ramirez L, Gertsenstein M, Nagy A, Lomeli H.(2005) Ectopic expression of KitD814Y in spermatids of transgenic mice, interferes with sperm morphogenesis. Dev Dyn.233(1):29-40.

136.Jun K. Takeuchi, Maria Mileikovskaia, Kazuko Koshiba-Takeuchi, AnaleahB. Heidt, Alessandro D. Mori, Eric P. Arruda, Marina Gertsenstein,Romain Georges, Lorinda Davidson, Rong Mo, Chi-chung Hui, R. MarkHenkelman, Mona Nemer, Brian L. Black, Andras Nagy and Benoit G. Bruneau(2005) Tbx20 dose-dependently regulates transcription factor networksrequired for mouse heart and motoneuron development Development. 132(10):2463-74. Epub 2005 Apr 20.

135.Gusztav Belteki, Jody Haigh, Nikolett Kabacs, Katharina Haigh, KarenSison, Frank Costantini, Jeff Whitsett, Susan E. Quaggin and Andras Nagy(2005) Conditional and inducible transgene expression in mice throughthe combinatorial use of Cre-mediated recombination and tetracyclineinduction. Nucleic Acids Research 2005 33(5):e51; doi:10.1093/nar/gni051

134.Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T,Meuth S, Nagy A, Greene RW, Nestler EJ. (2004) Essential role ofbrain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10827-32. Epub 2004 Jul 12. PMID: 15249684

133. Quaggin S. E., Chan, A and Nagy, A (2004) Genetic manipulation of mice to study cardiovascular disease. Drug Discovery Today: Disease Models Volume 1, Issue 3, 243-248

132.Vintersten K, Monetti C, Gertsenstein M, Zhang P, Laszlo L, Biechele S, NagyA.(2004) Mouse in red: Red fluorescent protein expression in mouse EScells, embryos, and adult animals. genesis. 2004 Dec 9;40(4):241-246

131.Ramos-Mejia V, Escalante-Alcalde D, Kunath T, Ramirez L, GertsensteinM, Nagy A, Lomeli H. (2004) Phenotypic analyses of mouse embryos withubiquitous expression of Oct4: Effects on mid-hindbrain patterning andgene expression. Dev Dyn. 2004 Dec 3;232(1):180-190

130.Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A,Taniguchi M, Kolodkin AL, Ginty DD, Shima DT, Ruhrberg C.(2004) Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve.Genes Dev. 2004 Nov 15;18(22):2822-34.

129.Kehler J, Tolkunova E, Koschorz B, Pesce M, Gentile L, Boiani M, LomeliH, Nagy A, McLaughlin KJ, Scholer HR, Tomilin A. (2004) Oct4 isrequired for primordial germ cell survival. EMBO Rep. 2004 Nov;5(11):1078-83.

128.Korets-Smith E, Lindemann L, Tucker KL, Jiang C, Kabacs N, Belteki G,Haigh J, Gertsenstein M, Nagy A. (2004) Cre recombinase specificitydefined by the tau locus.genesis. 2004 Nov;40(3):131-8.

127.Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A.,Semenkovich, CF., Gordon, J. I. (2004) The gut microbiota as anenvironmental factor that regulates fat storage. Proc. Natl. Acad. Sci. U S A. 2004 Nov 2;101(44):15718-23.

126. Haigh JJ and Nagy A (2004) Whole Mount Analysis of the Embryonic Vasculature. Methods in Endothelial Cell Biology. Series : Springer Lab Manuals Augustin, Hellmut G. (Ed.) p. 325-336.

125.Ding H, Wu X, Bostrom H, Kim I, Wong N, Tsoi B, O'Rourke M, Koh GY,Soriano P, Betsholtz C, Hart TC, Marazita ML, Field LL, Tam PP, Nagy A.(2004) A specific requirement for PDGF-C in palate formation andPDGFR-alpha signaling. Nature Genetics 2004 Oct;36(10):1111-6. Sep 7 Epub 2004 Sep 07

124.Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, DoveWF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, InselTR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, PollockJD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P,Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM,Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, YancopoulosGD, Young SG, Zambrowicz B.(2004) The knockout mouse project. Nature Genetics 36: 921 - 924

123.Hao Ding, Mike Schertzer, Xiaoli Wu, Marina Gertsenstein, Sara Selig,Makoto Kammori, Reza Pourvali, Steven Poon, Irma Vulto, ElizabethChavez, Patrick P.L. Tam, Andras Nagy, and Peter M. Lansdorp (2004).Regulation of Murine Telomere Length by Rtel: An Essential Gene Encodinga Helicase-like Protein. Cell Vol 117, 873-886, 25 June 2004

122.Nordal RA, Nagy A, Pintilie M, Wong CS.(2004) Hypoxia andhypoxia-inducible factor-1 target genes in central nervous systemradiation injury: a role for vascular endothelial growth factor. Clin Cancer Res. 2004 May 15;10(10):3342-3353.

121.Haigh JJ, Ema M, Haigh K, Gertsenstein M, Greer P, Rossant J, Nagy A,Wagner EF. (2004) Activated Fps/Fes partially rescues the in vivodevelopmental potential of Flk1-deficient vascular progenitor cells. Blood 2004 Feb 1;103(3):912-920.

120.Martin R, Lahlil R, Damert A, Miquerol L, Nagy A, Keller G, Hoang T.(2004) SCL interacts with VEGF to suppress apoptosis at the onset ofhematopoiesis. Development. 2004 Feb;131(3):693-702.

119.Duan LJ, Nagy A, Fong GH. (2003) Gastrulation and angiogenesis, notendothelial specification, is sensitive to partial deficiency invascular endothelial growth factor-a in mice. Biol Reprod. 2003 Dec;69(6):1852-8.

118.Viswanathan S, Benatar T, Mileikovsky M, Lauffenburger DA, Nagy A,Zandstra PW. (2003) Supplementation-dependent differences in the ratesof embryonic stem cell self-renewal, differentiation, and apoptosis. Biotechnol Bioeng. 84(5):505-17

117.Haigh JJ, Gerhardt H, Morelli P, Haigh K, Tsien J, Damert A, MiquerolL, Muhlner U, Klein R, Ferrara N, Wagner EF, Betsholtz C, and Nagy A(2003) Cortical and retinal defects caused by dosage dependentreductions in VEGF-A. Dev. Biol. 262: 225-241

116.Viloria-Petit A, Miquerol L, Yu JL, Gertsenstein M, Sheehan C, May L,Henkin J, Lobe C, Nagy A, Kerbel RS, Rak J. (2003) Contrasting effectsof VEGF gene disruption in embryonic stem cell-derived versusoncogene-induced tumors. EMBO J. 2003 Aug 15;22(16):4091-102.

115.Metzler M, Li B, Gan L, Georgiou J, Gutekunst C-A, Wang Y, Torre E,Devon RS, Oh R, Legendre-Guillemin V, Rich M, Alvarez C, Gertsenstein M,McPherson PS, Nagy A, Wang YT, Roder JC, Raymond LA and Hayden MR(2003) Disruption of the Endocytic Protein HIP1 Results in NeurologicalDeficits and Decreased AMPA Receptor Trafficking. EMBO J. 2003 Jul 1;22(13):3254-66.

114.Fitzpatrick LA, Buzas E, Gagne TJ, Nagy A, Horvath C, Ferencz V, MesterA, Kari B, Ruan M, Falus A, Barsony J. (2003) Targeted deletion ofhistidine decarboxylase gene in mice increases bone formation andprotects against ovariectomy-induced bone loss. Proc Natl Acad Sci U S A. 2003 Apr 25

113. Fülöp AK, Földes A, Buzás E, Hegyi K, Miklós IH, Romics L, Kleiber M, Nagy A, Falus A, Kovács KJ. (2003) Hyperleptinemia,visceral adiposity, and decreased glucose tolerance in mice with atargeted disruption of the histidine decarboxylase gene. Endocrinology. 2003 Oct;144(10):4306-14.

112.Hunyady B, Zolyomi A, Czimmer J, Mozsik G, Kozicz T, Buzas E, Tanaka S,Ichikawa A, Nagy A, Palkovits M, Falus A. (2003) Expanded parietal cellpool in transgenic mice unable to synthesize histamine. Scand J Gastroenterol. 2003 Feb;38(2):13

111.Apicelli AJ, Uhlmann EJ, Baldwin RL, Ding H, Nagy A, Guha A, GutmannDH. (2003) Role of the Rap1 GTPase in astrocyte growth regulation. Glia. May;42(3):225-3

110.Kimura T, Suzuki A, Fujita Y, Yomogida K, Lomeli H, Asada N, Ikeuchi M,Nagy A, Mak TW, Nakano T. (2003) Conditional loss of PTEN leads totesticular teratoma and enhances embryonic germ cell production. Development130(8):1691-1700

109.Ding H, Shannon P, Lau N, Wu X, Roncari L, Baldwin RL, Takebayashi H,Nagy A, Gutmann DH, Guha A. (2003) Oligodendrogliomas Result from theExpression of an Activated Mutant Epidermal Growth Factor Receptor in aRAS Transgenic Mouse Astrocytoma Model. Cancer Res.63(5):1106-13.

108.Eremina V, Sood M, Haigh J, Nagy A, Lajoie G, Ferrara N, Gerber HP,Kikkawa Y, Miner JH, Quaggin SE. (2003) Glomerular-specific alterationsof VEGF-A expression lead to distinct congenital and acquired renaldiseases. J Clin Invest111(5):707-716

107.Mezey E, Nagy A, Szalayova I, Key S, Bratincsak A, Baffi J, Shahar T.(2003) Comment on "Failure of bone marrow cells to transdifferentiateinto neural cells in vivo".
Science299(5610):1184

106. Nagy, A., Perrimon, N., Sandmeyer, S. and Plasterk, R. (2003) Tailoring the genome; the power of genetic approaches. Nature Genetics Mar;33 Suppl:276-84

105.Belteki, G., David W. Ow, D.W. and Nagy, A. (2003) Site-specificcassette exchange and germline transmission with mouse ES cellsexpressing PhiC31 integrase. Nature Biotechnology Mar;21(3):321-4.

104.Lau N, Uhlmann EJ, Von Lintig FC, Nagy A, Boss GR, Gutmann DH, GuhaA.(2003) Rap1 activity is elevated in malignant astrocytomas independentof tuberous sclerosis complex-2 gene expression. Int J Oncol.22(1):195-200.

103. Nagy A., Gertsenstein M., Vintersten K. and Behringer R. (2003) Manipulating the Mouse Embryo; A Laboratory manual. 3rd edition, Cold Spring Harbor Press, Cold Spring Harbor, New York

102.Behrens A, Haigh J, Mechta-Grigoriou F, Nagy A, Yaniv M, Wagner EF.(2003) Impaired intervertebral disc formation in the absence of Jun. Development. 130(1):103-109.

101. Maatman R, Gertsenstein M, de Meijer E, Nagy A, Vintersten K. (2003) Aggregation of embryos and embryonic stem cells. Methods Mol Biol. 209:201-30.

100.Radomska HS, Gonzalez DA, Okuno Y, Iwasaki H, Nagy A, Akashi K, Tenen DG, Huettner CS. (2002) Transgenic targeting with regulatory elements of the human CD34 gene. Blood. 2002 Aug 15 [epub ahead of print]

99.Pap E, Racz K, Kovacs JK, Varga I, Buza E, Madarasz B, Foldes C, SzalaiC, Watanabe T, Ohtsu H, Ichikawa A, Nagy A, Falus A. (2002) Histidinedecarboxylase deficiency in gene knockout mice elevates male sex steroidproduction. J Endocrinol 175(1):193-199.

98.Makabe-Kobayashi Y, Hori Y, Adachi T, Ishigaki-Suzuki S, Kikuchi Y,Kagaya Y, Shirato K, Nagy A, Ujike A, Takai T, Watanabe T, Ohtsu H.(2002) The control effect of histamine on body temperature andrespiratory function in IgE-dependent systemic anaphylaxis.
J Allergy Clin Immunol. 10(2):298-303.

97.Hori Y, Nihei Y, Kurokawa Y, Kuramasu A, Makabe-Kobayashi Y, Terui T,Doi H, Satomi S, Sakurai E, Nagy A, Watanabe T, Ohtsu H. (2002)Accelerated clearance of Escherichia coli in experimental peritonitis ofhistamine-deficient mice. J Immunol. 169(4):1978-83.

96.Perl AK, Wert SE, Nagy A, Lobe CG, Whitsett JA. (2002) Earlyrestriction of peripheral and proximal cell lineages during formation ofthe lung. Proc Natl Acad Sci U S A. 99(16):10482-7.

95.Ohtsu H, Kuramasu A, Tanaka S, Terui T, Hirasawa N, Hara M,Makabe-Kobayashi Y, Yamada N, Yanai K, Sakurai E, Okada M, Ohuchi K,Ichikawa A, Nagy A, Watanabe T. (2002) Plasma extravasation induced bydietary supplemented histamine in histamine-free mice. Eur J Immunol.32(6):1698-708.

94.Logan, M,, Martin, J.M., Nagy, A., Lobe, C., Olson, E.n. and Tabin C.J.(2002) Expression of Cre Recombinase in the Developing Mouse Limb BudDriven by a PrxI Enhancer. genesis 33: 77-80.

93.Hadjantonakis, A.-K., Macmaster, S. and Nagy, A. (2002) Embryonic stemcells and mice expressing different GFP variants for multiplenon-invasive reporter usage within a single animal. BMC Biotechnology 2002 2: 11

92.Bayle JH, Randazzo F, Johnen G, Kaufman S, Nagy A, Rossant J, CrabtreeG.(2002) Hyperphenylalaninemia and impaired glucose tolerance in micelacking the bifunctional DCoH gene. J Biol Chem 2002 May 13; [epub ahead of print]

91.Chan EY, Nasir J, Gutekunst CA, Coleman S, Maclean A, Maas A, MetzlerM, Gertsenstein M, Ross CA, Nagy A, Hayden MR.(2002) Targeted disruptionof Huntingtin-associated protein-1 (Hap1) results in postnatal deathdue to depressed feeding behavior. Hum Mol Genet 11(8):945-959

90.Wiener Z, Andrásfalvy M, Pállinger E, Kovács P, Szalai C, Erdei A, Tóth S, Nagy A, Falus A. Bone marrow-derived mast cell differentiation is strongly reduced in histidine decarboxylaseknockout, histamine-free mice. International Immunology  2002. Apr.  14(4): 381-387.  PMID: 11934874

89.Damert, A., Lucile Miquerol, L., Gertsenstein, M., Risau, W. and Nagy,A. 2002. Insufficient VEGF-A activity in yolk sac endoderm compromiseshaematopoietic and endothelial differentiation. Development129(8):1881-1892.

88. Ding, H., Wu, X. and Nagy, A. (2002) Mice with Cre recombinase activatable PDGF-C expression. genesis32(2): 181-183.

87.Horváth, B. V., Falus, A., Tóth, S., Szalai, Cs., Lázár-Molnár, E.,Holub, M. Cs., Buzás, E., Nagy, A. and Fulop, A. K. (2002) Inverseregulation of interleukin-6 (IL-6) and IL-6 receptor in histaminedeficient histidine decarboxylase-knock-out mice. Immunology Letters80(3):151-154.

86.Tanaka, S., Hamada, K., Yamada, N., Sugita, Y., Tonai, S. Hunyadi, B.,Palkovits, M., Falus, A., Watanabe, T., Okabe, S., Ohtsu, H., Ichikawa,A. and Nagy, A. (2002) Gastric acid secretion in L-histidinedecarboxylase deficient mice. Gastroenterology 122(1):145-155.

85. Gertsenstein, M., Lobe, C. and Nagy, A. (2002) ES cell mediated conditional transgenesis. In Embryonic Stem Cells: Methods and Protocols Edited by Kursad Turksen, Humana Press's Methods in Molecular Biology185:285-307

84.Kinder, S. J., Tsang, T. E., Wakamiya, M., Sasaki, H., Behringer, R.R., Nagy, A and Tam P. P. L. (2001) The organizer of the mouse gastrulais composed of a dynamic population of progenitor cells for the axialmesoderm. Development128: 3623-3634.

83.Ohtsu H, Tanaka S, Terui T, Hori Y, Makabe-Kobayashi Y, Pejler G,Tchougounova E, Hellman L, Gertsenstein M, Hirasawa N, Sakurai E, BuzasE, Kovacs P, Csaba G, Kittel A, Okada M, Hara M, Mar L, Numayama-TsurutaK, Ishigaki-Suzuki S, Ohuchi K, Ichikawa A, Falus A, Watanabe T, NagyA. (2001) Mice lacking histidine decarboxylase exhibit abnormal mastcells. FEBS Lett. 502(1-2): 53-56.

82.Wang, J., Mager, J., Chen, Y., Schneider, E., Cross, J.C., Nagy, A. andMagnuson, T. (2001) Imprinted X inactivation maintained by a mouse Polycomb group gene. Nature Genetics28: 371-375.

81.Hegyi K, Fulop AK, Toth S, Buzas E, Watanabe T, Ohtsu H, Ichikawa A,Nagy A, Falus A. (2001) Histamine deficiency suppresses murinehaptoglobin production and modifies hepatic protein tyrosinephosphorylation. Cell. Mol. Life Sci. 58: 850–854.

80.Csankovszki, Gy., Nagy, A. and Jaenisch R. (2001) Synergism of XistRNA, DNA Methylation, and Histone Hypoacetylation in Maintaining XChromosome Inactivation. The Journal of Cell Biology, 153(4): 773–783.

79. Zandstra, PW., Nagy, A. (2001) Stem Cell Bioengeneering. Annual review of biomedical engineering.3:275-305.

78.Ding, H., Roncari, L., Shannon, P., Wu, X., Lau, N., Karaskova, J.,Gutmann, D. H., Squire, J. A., Nagy, A. and Guha, A. (2001)Astrocyte-specific Expression of Activated p21-ras Results in MalignantAstrocytoma Formation in a Transgenic Mouse Model of Human Gliomas. Cancer Research6: 3826–3836.

77. Nagy, A. and Rossant, J. (2001) Chimaeras and mosaics for dissecting complex mutant phenotypes Int. J. Dev. Biol. 45: 577-582.

76.Yu, JL., Rak, JW., Carmeliet, P., Nagy, A., Kerbel, RS., Coomber, BL.(2001) Heterogeneous Vascular Dependence of Tumor Cell Populations. Am J Pathol. Apr;158(4):1325-1334.

75.Pinter, E., Haigh, J., Nagy, A., Madri, JA. (2001)Hyperglycemia-Induced Vasculopathy in the Murine Conceptus Is Mediatedvia Reductions of VEGF-A Expression and VEGF Receptor Activation. Am J Pathol. Apr;158(4):1199-1206.

74.Hadjantonakis, A.-K., Cox, L. L., 2,5, Tam, P. P. L. and Nagy, A.(2001) An X-linked GFP transgene reveals unexpected paternalX-chromosome activity in trophoblastic giant cells of the mouseplacenta. genesis 29: 133-140.

73.Lefebvre, L., Dionne, N., Karaskova, J., Squire, J. A. and Nagy, A.(2001) Selection for transgene homozygosity in ES cells results inextensive loss of heterozygosity. Nature Genetics27: 257-258.

72. Hadjantonakis, A.-K. and Nagy, A. (2001) The color of mice: in the light of GFP-variant reporters. Histochemistry and Cell Biology 115: 49-58.

71. Nagy, A. and Mar, L. (2001) Creation and Use of a Cre Recombinase Transgenic Database. In Methods in Molecular Biology, vol. 158:95-106.: Gene Knockout Protocols Edited by: M. J. Tymms and I. Kola © Humana Press Inc., Totowa, NJ

70. Tanaka, M., Hadjantonakis A.-K., and Nagy, A. (2001) Combining ES Cells and Diploid and Tetraploid Embryos. In Methods in Molecular Biology, vol. 158:135-54: Gene Knockout Protocols Edited by: M. J. Tymms and I. Kola © Humana Press Inc., Totowa, NJ

69.Hemberger, M., Kurz, H., Orth, A., Otto, S., Luttges, A., Elliott, R.,Nagy, A., Tan, S-S., Tam, P., Zechner, U., Fundele, R.H. (2001) Geneticand Developmental Analysis of X-Inactivation Hybrid Mice Suggests a Rolefor the Y Chromosome in Placental Dysplasia. Genetics157: 341-348.

68.Ding, H., Roncari, L., Wu, X., Lau, N., Shannon, P., Nagy, A. and Guha,A. (2001) Expression and Hypoxic Regulation of Angiopoietins in HumanAstrocytomas. Neurooncology, 3(1): 1-10.

67.Adelman, D.M., Gertsenstein, M., Nagy, A., M. Simon, C, and Maltepe, E.(2000) Placental cell fates are regulated in vivo by HIF-mediatedhypoxia responses. Genes and Development 14: 3191-3203.

66.Pennisi, D., Bowles, J., Nagy, A., Muscat, G. and Koopman, P. (2000)Mice null for Sox18 are viable and display a mild coat defect. Molecular and Cellular Biology 20: 9331-9336.

65.Novak, A., Guo, C., Yang, W., Nagy, A. and Lobe, C. L. (2000) Z/EG, adouble reporter mouse line that expresses Enhanced Green FluorescentProtein upon Cre-mediated excision. genesis 28: 147-155.

64.Ding, H., Wu, X., Roncari, L., Lau, N., Shannon, P., Nagy, A. and Guha,A. (2000) Expression and regulation of Neuropilin-1 in humanastrocytomas. International Journal of Cancer 88: 584-592.

63. Ding, H., Wu, X., Kim, I., Tam, P.P.L., Koh , G.Y and Nagy, A. (2000) The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis. Mech. Dev. 96(2): 209-213.

62.Miquerol, L., Langille, B. L. and Nagy, A. (2000) Embryonic Developmentis Disrupted by Modest Increases in Vascular Endothelial Growth FactorGene Expression. Development127(18): 3941-3946.

61.Hadjantonakis, A.-K. and Nagy, A. (2000) Use of FACS for the isolationof individual cells from transgenic mice harboring a GFP reporter. genesis 27: 95-98.

60. Hardouin, N. and Nagy, A. (2000) Gene-trap based target site for Cre-mediated transgenic insertion. genesis 26(4): 245-252.

59. Hardouin, N. and Nagy, A. (2000) Mini review: Mouse models for human disease. Clinical Genetics 57:237-244.

58. Nagy, A. (2000) Cre recombinase: the universal reagent for genome tailoring. genesis 26(2): 99-109.

57.Lomelí, H., V. Ramos-Mejía, M. Gertsenstein, C.G. Lobe and A. Nagy(2000) Targeted insertion of Cre recombinase into the TNAP gene:excision in primordial germ cells. genesis 26(2): 116-117.

56. Nagy, A. and J. Rossant (1999). Production and analysis of ES-cell aggregation chimeras. In Gene Targeting: A Practical Approach (ed. A. Joyner, Second Edition), Oxford University Press Inc., New York, pp. 177-206.

55.Kinder, S.J., T.E. Tsang, G.A. Quinlan, A-K. Hadjantonakis, A. Nagy andP.Tam (1999) The orderly allocation of mesodermal cells to theextraembryonic structures and the anterior-posterior axis duringgastrulation of the mouse embryo. Development, 126(21):4691-4701.

54.Zhang, J., A. Shehabeldin, L.A. G. da Cruz, J. Butler, A-K Somani, M.McGavin, I. Kozieradzki, A. O. dos Santos, A. Nagy, S. Grinstein, J. M.Penninger, K. A. Siminovitch (1999). Antigen Receptor-induced Activationand Cytoskeletal Rearrangement are Impared in Wiskott-Aldrich SyndromeProtein-deficient Lymphocytes. J. Exp. Med. 190 (9): 1-13.

53.Tanaka, M., M. Puchyr, M. Gertsenstein, K. Harpal, R. Jaenisch, J.Rossant and A. Nagy (1999). Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech Dev Sep 1; 87(1-2): 129-142.

52.Miquerol, L., M. Gertsenstein, K. Harpal, J.Rossant and A. Nagy (1999).Multiple developmental roles of VEGF suggested by a LacZ-tagged allele.Dev Biol Aug 15; 212(2): 307-322.

51.Carmeliet, P., Y-S. Ng, D. Nuyens, G. Theilmeier, K. Brusselmans, I.Cornelissen, E. Ehler, V. V. Kakkar, I. Stalmans, V. Mattot, J-C.Perriard, M. Dewerchin, W. Flameng, A. Nagy, F. Lupu, L. Moons, D.Collen, P. A. D'Amore & D. T. Shima (1999). Impaired myocardialangiogenesis and ischemic cardiomyopathy in mice lacking the vascularendothelial growth factor isoforms VEGF164 and VEGF188 Nat Medicine 5(5): 495 - 502.

50.Lobe C.G., Koop, K.E., Kreppner, W., Lomeli, H., Gertsenstein, M.,Nagy, A. (1999). Z/AP, a Double Reporter for Cre-Mediated Recombination.Dev Biol. Apr 15; 208(2):281-292.

49.NozakiM., Ohishi K., Yamada N., Kinoshita T., Nagy A., Takeda J. (1999)Developmental abnormalities ofglycosylphosphatidylinositol-anchor-deficient embryos revealed byCre/loxP system. Lab Invest Mar;79(3):293-299.

48. Rossant, J. and Nagy, A. (1999) In search of the tabula rasa of human cells. Nat Biotechnol. Jan;17(1):23-24. No abstract available.

47.Tanaka S, T. Kunath, A-K. Hadjantonakis, A. Nagy, J. Rossant (1998).Promotion of trophoblast stem cell proliferation by FGF4. Science282(5396), 2072-2075.

46.Hadjantonakis, A.-K., M. Pirity and A. Nagy (1998). Cre recombinasemediated alterations of the mouse genome for the study of embryonicdevelopment. In Methods in Molecular Bilogy, Vertebrate Embryology (eds. P.T. Sharpe and I.J. Mason) 97: 101-122.

45.Hadjantonakis, A-K., M. Gertsenstein, M. Ikawa, M. Okabe and A. Nagy(1998). Generation of green fluorescent mice by germline transmission ofgreen flourescent ES cells. Mech Dev. 76, 79-90.

44.Hadjantonakis, A-K., M. Gertsenstein, M. Ikawa, M. Okabe and A. Nagy(1998). Non-invasive sexing of preimplantation stage mammalian embryos. Nat Genet. 19(3), 220-222.

43. Pirity, M., A.-K. Hadjantonakis and A. Nagy (1998). Embryonal stem cells, creating transgenic animals. In Methods Cell Biol . (eds. J.P. Mather and D. Barnes). Academic Press, San Diego 57, 279-293 .

42. Rossant, J., F. Guillemot, M. Tanaka, K. Latham, M. Gertsenstein and A. Nagy (1998). Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation. Mech Dev. 73(2), 183-191.

41.Nagy, A., C. Moens, E. Ivanyi, J. Pawling, M. Gertsenstein K.Hadjantonakis, M. Pirity and J. Rossant (1998). Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles. Current Biology 8, 661-664.

40. Lobe, C.G. and A. Nagy (1998). Conditional genome alteration in mice. BioEssays 20, 200-208.

39. Tanaka, M., M. Gertsenstein, J. Rossant and A. Nagy (1997). Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev. Biol. 190, 55-65.

38.Carmeliet, P., L. Moons, M. Dewerchin, N. Mackman, T. Luther, G.Breier, V. Ploplis, M. Muller, A. Nagy, E. Plow, R. Gerard, T.Edgington, W. Risau and D. Collen (1997). Insights in vessel developmentand vascular disorders using targeted inactivation and transfer ofvascular endothelial growth factor, the tissue factor receptor, and theplasminogen system. Ann. N. Y. Acad. Sci. 811, 191-206.

37. Nagy, A. (1997). Formation of mouse chimeric embryos from ES cells. In Transgenic Animals: Generation and Use (ed. L.-M. Houdebine), Harwood Academic Publishers, Amsterdam, pp. 167-172.

36.Duncan, S.A., A. Nagy, and W. Chan (1997). Murine gastrulation requiresHNF-4 regulated gene expression in the visceral endoderm: tetraploidrescue of Hnf-4-/- embryos. Development 124, 279-287.

35. Nagy, A. (1996). Engineering the mouse genome. In Mammalian Development (ed. P. Lonai), Harwood Academic Publishers, Amsterdam, pp. 339-371.

34.Carmeliet, P., V. Ferreira, G. Breier, S. Pollefeyt, L. Kieckens, M.Gertsenstein, M. Fahrig, A. Vandenhoeck, K. Harpal, C. Eberhardt, C.Declerq, J. Pawling, L. Moons, D. Collen, W. Risau and A. Nagy(1996). Abnormal blood vessel development and lethality in embryoslacking a single vascular endothelial growth factor allele. Nature 380, 435-439.

33. Nagy, A. and J. Rossant (1996). Targeted mutagenesis: analysis of phenotype without germ line transmission. J. Clin. Invest. 97, 1360-1365.

32.Forrester, L., A. Nagy, M. Sam, A. Watt, L. Stevenson, A. Bernstein,A.L. Joyner and W. Wurst (1996). An induction gene trap screen inembryonic stem cells: identification of genes that respond to retinoicacid in vitro. Proc. Natl. Acad. Sci. USA 93, 1677-1682.

31. Rossant, J. and A. Nagy (1995). Genome engineering: the new mouse genetics. Nat. Med. 1, 592-594.

30.Guillemot, F., T. Caspary, S.M. Tilghman, N.G. Copeland, D.J. Gilbert,N.A. Jenkins, D.J. Anderson, A.L. Joyner, J. Rossant and A. Nagy (1995). Genomic imprinting of Mash-2, a mouse gene required for trophoblast development. Nat. Genet. 9, 235-241.

29. Guillemot, F., A. Nagy, A. Auerbach, J. Rossant and A.L. Joyner (1994). Essential role of Mash-2 in extraembryonic development. Nature 371, 333-336.

28. Chambers, C., J. Kang, J. Pawling, B. Huber, N. Hozumi and A. Nagy (1994). Exogenous Mtv-7superantigen expression in major histocompatibility complex class III-E- mice reconstituted with embryonic stem cell-derived hematopoieticstem cells. Proc. Natl. Acad. Sci. USA 91, 1138-1142.

27. Nagy, A. and J. Rossant (1993). Production of completely ES-cell derived fetuses. In Gene Targeting: A Practical Approach (ed. A. Joyner), Oxford University Press Inc., New York, pp. 147-179.

26.Wood, S.A., N.D. Allen, J. Rossant, A. Auerbach and A. Nagy (1993).Non-injection methods for the production of embryonic stem cell-embryochimaeras. Nature, 365, 87-89.

25.Nagy, A., J. Rossant, R. Nagy, W. Abramow-Newerly and J.C. Roder(1993). Derivation of completely cell culture-derived mice from earlypassage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-8428.

24. Rossant, J., C.B. Moens and A. Nagy (1993). Genome manipulation in embryonic stem cells. In Transgenic Modification of Germline and Somatic Cells (ed. R.B. Flawell and R.B. Heap), Chapman and Hall, London, pp. 69-77.

23. Rossant, J., C.B. Moens and A. Nagy (1993). Genome manipulation in embryonic stem cells. Phil. Trans. R. Soc. Lond. B 339, 207-215.

22.Rossant, J., E. Merentes-Diaz, E. Gocza, E. Ivanyi and A. Nagy (1991).Developmental potential of mouse embryonic stem cells. In Serono Symposium on Preimplantation Embryo Development (ed. B.D. Bavister), Springler-Verlag, N.Y., pp. 157-165.

21.Forrester, L.M., A. Bernstein, J. Rossant and A. Nagy (1991). Long-termreconstitution of the mouse hematopoietic system by embryonic stemcell-derived fetal liver. Proc. Natl. Acad. Sci. USA 88, 7514-7517.

20.Nagy, A., E. Gocza, E. Merentes-Diaz, V.R. Prideaux, E. Ivanyi, M.Markkula and J. Rossant (1990). Embryonic stem cells alone are able tosupport fetal development in the mouse. Development 110, 815-821.

19.Nagy, A., M. Markkula and M. Sass (1989). Systematic non-uniformdistribution of parthenogenetic cells in adult mouse chimeras. Development 106, 321-324.

18.Paldi, A., A. Nagy, M. Markkula, I. Barna and L. Dezso (1989).Postnatal development of parthenogenetic-fertilized mouse aggregationchimeras. Development 105, 115-118.

17.Nagy, A., A. Paldi, L. Dezso, L. Varga and A. Magyar (1987). Prenatalfate of parthenogenetic cells in mouse aggregation chimeras. Development 101, 67-71.