Lunenfeld-Tanenbaum Research Institute

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 Woodgett Lab 

 Apoptosis

Stress signal transduction pathways

studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein

 

 Nutty Quiz

 

studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription We are studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription factors and is activated by a wide variety of cellular stresses. Signalling components include SAPKs, SEK1, MEKK, MLK3, HPK and GC kinase. Targets include c-Jun and ATF2. Here is a clickable image map describing the components of the three known mammalian MAPK-related pathways.

Glycogen synthase kinase-3 biology

Study of glycogen synthase kinase-3 (GSK-3) continues to unearth surprises and we are actively investigating its function in diverse species using genetics, biochemistry and cell biology. Pages detailing the regulation, substrates and physiological functions of this kinase and its importance in insulin and Wnt signalling are in preparation. GSK-3 is specifically inhibited by lithium. Is this kinase a therapeutic target for bipolar disorders?

See the following recent publications for further details.

Nuclear Oncoproteins

In particular, post translational control of transcription factors that are also oncogenes such as c-Jun, c-Fos and c-Myc.

Protein kinases

A protein kinase resource web site devoted to protein kinases has recently been set up at the University of San Diego Supercomputing Centre. It's full of useful information. Here's a list of all the known budding yeast protein kinases extracted from the yeast genome database (with links to the genes). A comprehensive list of all protein kinases (720K) has also been compiled by the folks at the protein kinase resource (contains nearly 3,713 entries!).

Apoptosis

The stress-activated protein kinase pathways play many roles in cells including affecting cell viability in response to physical and chemical insult.

Methods and protocols

Support

Our laboratory is supported by research grants and fellowships from the CIHR, the Canadian Cancer Society/National Cancer Institute of Canada, the Terry Fox Foundation, and the Howard Hughes Medical Institute International Scholars Program
 

 

 

          
  

Sig. Maps

   

MAPK

    

Stresses

    

Mitogens

    

NGF

    

TNF

    

CD40

    

RTK

    

GRB2

    

SOS

    

Ras

    

Raf

    

MEK

    

MAP-K

    

RSK

    

Rac

    

HPK

    

GCK

   

Wnt Rest

   

Wnt Active

  

Lists

   

Labs

  

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People

   

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