Budding Yeast Protein Kinases

Since the entire S. cerevisiae genome has now been sequenced, it makes sense to use it as a prototype for looking for members of gene families. Thus, 109 protein kinases have been identified by sequence.

The following is a list of all of the genes from a keyword search of "protein kinase" from the Yeast Protein Database. It has been sorted to remove non-protein kinases but kinase regulatory proteins have been left in. The entries have links to the gene files in the YPD. Please email me if you find errors or entries I missed.

• BCK1/(SLK1)/SSP31/LAS3/SAP3/J0906/YJL095W Serine/threonine protein kinase of the MEKK family, involved in the cell wall integrity pathway.
   
• BCK2/CTR7/(SLK1)/YER167W Serine/threonine protein kinase of the protein kinase C pathway.
   
• BCY1/SRA1/(REG1)/YIL033C Regulatory subunit of cAMP-dependent protein kinases.
   
• BMH1/APR6/YER177W Homolog of mammalian 14-3-3 protein, has strong similarity to Bmh2p.
   
• BRO1/LPF2 Protein that interacts with components of the PKC1-MAP kinase pathway.
   
• BUB1 Serine/threonine protein kinase and checkpoint protein required for cell cycle arrest in response to loss of microtubule function.
   
• CDC15/YAR019C Protein kinase of the MAP kinase kinase kinase family essential for late nuclear division.
   
• CDC28/CDK1/SRM5/YBR1211/YBR160W Cyclin-dependent protein kinase essential for completion of START and for mitosis, associates with Cks1p and cyclins.
   
• CDC5/PKX2/MSD2/YM8270.03 Serine/threonine protein kinase required for exit from mitosis, ts mutants block after nuclear division.
   
• CDC7/SAS1/OAF2/D2855 Protein kinase required for initiation of DNA synthesis, for commitment to sporulation, for DNA repair, and for meiotic recombination.
   
• CKA1/YIL035C Casein kinase II, catalytic (alpha) subunit.
   
• CKA2/O2810 Casein kinase II, catalytic (alpha') subunit.
   
• CKB1 Casein kinase II, beta subunit.
   
• CKB2/OR26.32/O2756 Casein kinase II, beta' subunit.
   
• CKI3/YER123W Casein kinase I isoform.
   
• CKS1/YBR1011/YBR135W Protein associated with Cdc28p protein kinase, homolog of S. pombe suc1.
   
• CLA4/ERC10/N0450/YNL0450/YNL298W Serine/threonine protein kinase required for cytokinesis, has similarity to Ste20p.
   
• CLN1/YM9646.13 G1/S-specific cyclin, interacts with Cdc28p protein kinase to control events at START.
   
• CLN2/P0741 G1/S-specific cyclin, interacts with Cdc28p protein kinase to control events at START.
   
• CLN3/DAF1/WHI1/FUN10/YAL040C G1/S-specific cyclin, interacts with Cdc28p protein kinase to control events at START.
   
• CMK1/YFR014C Calcium/calmodulin dependent serine/threonine protein kinase (CaM kinase), type I.
   
• CMK2/O2325 Calcium/calmodulin dependent serine/threonine protein kinase (CaM kinase), type II.
   
• CTK1/YKL139W Carboxyl-terminal domain (CTD) kinase alpha subunit, cyclin-dependent protein kinase that phosphorylates C-terminal domain of RNA polymerase II large subunit.
   
• CTK2/YJL006C Carboxyl-terminal domain (CTD) kinase beta subunit, cyclin-related protein component that interacts with the cyclin-dependent protein kinase Ctk1p.
   
• CTK3/M_C296/YM8339.07 Carboxyl-terminal domain (CTD) kinase gamma subunit, associates with Ctk1p and Ctk2p.
   
• D2810 Protein with similarity to protein kinase Npr1p.
   
• D8035.10 Protein with similarity to probable protein kinase Hrc1081p.
   
• D8035.33 Protein kinase of unknown function, has similarity to Hrc1081p.
   
• DBF2 Serine/threonine protein kinase related to Dbf20p, required for events in anaphase/telophase.
   
• DBF20/P8283.6 Cell cycle protein kinase related to Dbf2p, involved in termination of M-phase.
   
• DBF4/DNA52/D4205/YD9609.07 Regulatory subunit for Cdc7p protein kinase, required for G1/S transition.
   
• ELM1/YKL261/YKL048C Serine/threonine protein kinase regulating pseudohyphal growth.
   
• FUS3/DAC2/YBL0303/YBL03.21/YBL016W Serine/threonine protein kinase of the MAP kinase family required for cell cycle arrest and for cell fusion during mating.
   
• G1615 Serine/threonine protein kinase of unknown function.
   
• G1618/BIE560 Serine/threonine protein kinase with similarity to Elm1p and Kin82p.
   
• GCN2/AAS1/D9954.16 Serine/threonine protein kinase that regulates initiation of translation by phosphoryation of eIF2alpha (Sui2p) .
   
• GIN4/D9719.13 Serine/threonine protein kinase with similarity to Ycl024p, growth inhibitory protein.
   
• HAL5/YJL165C Serine/threonine protein kinase involved in salt and pH tolerance.
   
• HOG1/SSK3/L9354.2/L2931 Serine/threonine protein kinase of MAP kinase (MAPK) family, involved in high-osmolarity signal transduction pathway.
   
• HRA655 Serine/threonine protein kinase with similarity to Ste20p.
   
• HRC1081 Serine/threonine protein kinase with similarity to mouse protein kinase C.
   
• HRR25/P1850 Casein kinase I, serine/threonine/tyrosine protein kinase, associated with DNA repair and meiosis.
   
• IME2/SME1/J0817/YJL106W Serine/threonine protein kinase and positive regulator of sporulation genes that is essential for initiation of meiosis.
   
• IPL1/P1820 Serine/threonine protein kinase involved in chromosome segregation.
   
• IRE1/ERN1/YHR079C Protein kinase and type I membrane protein involved in signal transduction from ER lumen to nucleus, part of the unfolded protein response.
   
• KIN1 Serine/threonine protein kinase, related to Kin2p and S. pombe KIN1.
   
• KIN2/L8004.3 Serine/threonine protein kinase, related to Kin1p and S. pombe KIN1.
   
• KIN28/ORF2330 Cyclin-dependent serine/threonine protein kinase component of transcription initiation factor TFIIH, phosphorylates C-terminal domain (CTD) of RNA polymerase large subunit.
   
• KIN3/NPK1/FUN52/YAR018C Serine/threonine protein kinase, null mutation has no phenotype.
   
• KIN4/KIN31/(KIN3)/O5220 Serine/threonine protein kinase related to Kin1p and Kin2p, catalytic domain is most related to Snf1p.
   
• KIN82/YCR1153/YCR091W Serine/threonine protein kinase of unknown function.
   
• KNS1/L124 Serine/threonine protein kinase of unknown function.
   
• KSP1/YHR082C Serine/threonine kinase, has similarity to casein kinase II and other serine/threonine protein kinases.
   
• KSS1 Serine/threonine protein kinase of the MAP kinase family, redundant with Fus3p for cell cycle arrest.
   
• LPI5 Serine/threonine protein kinase with similarity to Kin4p (GB:U43703).
   
• MCK1/(YPK1)/N0392/YNL307C Serine/threonine/tyrosine protein kinase (meiosis and centromere regulatory kinase), positive regulator of meiosis and spore formation.
   
• MDS1/RIM11/GSK3/YM9375.08 Serine/threonine protein kinase, homolog of mammalian GSK3.
   
• MEK1/MRE4/O6357 Serine/threonine protein kinase required for meiotic recombination.
   
• MIH1 M-phase inducing protein tyrosine phosphatase, dephosphorylates Cdc28p to activate kinase activity.
   
• MKK1/SSP32/O5095 Serine/threonine protein kinase of the MAP kinase kinase (MEK) family involved in cell wall integrity pathway.
   
• MKK2/SSP33/LPI6 Serine/threonine protein kinase of the MAP kinase kinase (MEK) family involved in cell wall integrity pathway.
   
• MPS1/RPK1/D2785 Serine/threonine/tyrosine protein kinase involved in spindle pole body duplication.
   
• MRK1 Serine/threonine protein kinase with similarity to Mds1p.
   
• MSS2/ORF2340 Serine/threonine protein kinase that suppresses the growth defect of snf3 mutants on low glucose.
   
• NPR1/N1631/YNL183C Serine/threonine protein kinase involved in regulating transport systems for nitrogen nutrients under conditions of nitrogen catabolite derepression.
   
• NRK1/KIC1/H8263.14/YHR102W Serine/threonine protein kinase that interacts with Cdc31p.
   
• ORF_1209713 Protein serine/threonine protein kinase of unknown function.
   
• ORF_530348 Serine/threonine protein kinase of unknown function.
   
• P8283.9 Protein with similarity to protein kinases Gcn2p, galactosyltransferase-associated protein kinase P58/Gtap, and the Raf proto-oncogene.
   
• PAK1/SYGP-ORF45/YER129W Protein kinase capable of suppressing DNA polymerase alpha mutations.
   
• PAN1/MDP3/MIP3/YIB6C/YIR006C Protein of unknown function.
   
• PBS2/HOG4/SFS4/SSK4/OSR1/YJL128C Tyrosine protein kinase of the MAP kinase kinase (MEK kinase) family, essential component of the high-osmolarity signal transduction pathway.
   
• PCL1/HCS26/N0536/YNL289W G1/S-specific cyclin that can interact with the Cdc28p-like kinase Pho85p.
   
• PHO80/TUP7/O2505 Cyclin that interacts with Pho85p protein kinase to regulate the phosphate pathway through phosphorylation of Pho4p.
   
• PHO81 Cyclin-dependent kinase (CDK) inhibitor for Pho80p/Pho85p complex, positive regulatory protein for phosphate pathway .
   
• PHO85/P7102_18A Cyclin-dependent protein kinase that interacts with cyclin Pho80p to regulate phosphate pathway, carries out hyperphosphorylation of Pho4p.
   
• PKC1/STT1/HPO2/CLY15/YBL0807/YBL105C Protein kinase C, regulates MAP kinase cascade involved in regulating cell wall metabolism.
   
• PTC1/TPD1/CWH47/KCS2/D2925 Protein serine/threonine phosphatase 2C, carries out dephosphorylation of Hog1p.
   
• RCK1/G1854 Serine/threonine protein kinase with similarity to Cmk1p, Cmk2p, and Cmk3p.
   
• RCK2/CMK3/CLK1/L9672.6 Calcium/calmodulin dependent serine/threonine protein kinase (CaM kinase).
   
• SCH1 Protein with weak similarity to protein kinase A inhibitor.
   
• SCH9/KOM1/YHR205W Serine/threonine protein kinase that is activated by cAMP, overproduction can suppress cdc25 mutant.
   
• SGV1/BUR1/P9584.8 Serine/threonine protein kinase involved in pheromone adaptation pathway and in cell cycle.
   
• SHA3/SKS1/LPB5 Serine/threonine protein kinase, suppressor of Hta1p mutations that cause aberrant transcription.
   
• SHO1/SSU81/YER118C Protein with an SH3 domain involved in the HOG1 high-osmolarity signal transduction pathway.
   
• SIC1/SDB25/L9449.8 P40 inhibitor of Cdc28p-Clb protein kinase complex.
  SLN1/YPD2/YIL147C Two-component signal transducer with both a histidine kinase domain and a receiver domain that functions in the high osmolarity signal transduction pathway.
   
• SLT2/MPK1/SLK2/BYC2/YHR030C Serine/threonine protein kinase of MAP kinase family involved in the cell wall integrity pathway.
   
• SMK1/YP9499.10/YPR048W Sporulation-specific MAP kinase required for completion of sporulation.
   
• SNF1/CAT1/CCR1/PAS14/HAF3/D8035.20 Serine/threonine protein kinase essential for derepression of glucose-repressed genes, acts with Snf4p.
   
• SOK1/YD8119.12 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase.
   
• SOK2/YM9711.03 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase.
   
• SPK1/RAD53/MEC2/SAD1/P2588 Serine/threonine/tyrosine protein kinase with a checkpoint function in S and G2.
   
• SPS1/D9719.27 Serine/threonine protein kinase involved in middle/late stage of meiosis.
   
• SSK1 Two-component signal transducer that receives phosphate from Sln1p as part of the high osmolarity signal transduction pathway.
   
• SSK2/N3276/YNR031C Map kinase kinase kinase of the high osmolarity signal transduction pathway.
   
• SSK22/YCR073C Map kinase kinase kinase with strong similarity to Ssk2p, participates in the high osmolarity signal transduction pathway.
   
• SSN3/UME5/SRB10/(ARE1)/P7102_08 Cyclin-dependent serine/threonine protein kinase of the RNA polymerase II holoenzyme complex and Kornberg's mediator (SRB) subcomplex.
   
• STE11/L8039.10 Serine/threonine protein kinase of the MEKK family, component of the pheromone pathway and a pathway regulating filamentous growth.
   
• STE20/YHL007C Serine/threonine protein kinase of the pheromone pathway, also participates in pathway regulating filamentous growth.
   
• STE5/NUL3/YD8557.12 Pheromone pathway protein involved in a complex with Fus3p, Ste7p, and Ste11p.
   
• STE50/YCL032W Protein that interacts with Gpa1p, Ste4, and Ste18 to regulate adaptation to pheromone.
   
• STE7/D1525 Serine/threonine/tyrosine protein kinase of MAP kinase kinase (MEK) family, component of the pheromone pathway and a pathway regulating filamentous growth.
   
• SWE1/YJL187C Serine/tyrosine dual specificity protein kinase able to phosphorylate Cdc28p on tyrosine and inhibit its activity.
   
• TEL1/YBL0706/YBL088C Protein involved in controlling telomere length, may have posphatidylinositol 3-kinase or protein kinase activity.
   
• TPK1/SRA3/PKA1/PK25/YJL164C CAMP-dependent protein kinase 1, catalytic chain.
   
• TPK2 CAMP-dependent protein kinase 2, catalytic chain.
   
• TPK3 CAMP-dependent protein kinase 3, catalytic chain.
   
•  
• VPS15 Serine/threonine protein kinase involved in vacuolar protein sorting.
   
• YAK1/YJL141C Serine/threonine protein kinase that suppresses loss of Tpk1p + Tpk2p + Tpk3p.
   
• YAL017W/YAL002/FUN31 Serine/threonine protein kinase of unknown function.
   
• YBR028C/YBR0312 Serine/threonine protein kinase with similarity to Ypk2p/Ykr2p and Ypk1p.
   
• YBR059C/YBR0419 Serine/threonine protein kinase of unknown function.
   
• YBR274W/YBR1742 Protein kinase with similarity to members of the growth factor and cytokine receptor family.
   
• YCK1/CKI2/YHR135C Casein kinase I isoform.
   
• YCK2/(CKI1)/(CKI)/N1755/YNL154C Casein kinase I isoform.
   
• YCR008W/YCR101/YCR046 Protein with similarity to Npr1p protein kinase.
   
• YD8419.14 Serine/threonine protein kinase with similarity to P08092 negative regulator of sexual conjugation and meiosis.
   
• YD9727.05 Protein with similarity to FGGY protein kinase family.
   
• YFL029C Serine/threonine protein kinase with similarity to S. pombe csk1 protein.
   
• YFL033C Serine/threonine protein kinase with similarity to S. pombe CEK1 protein kinase.
   
• YIL095W/(PAK1) Serine/threonine protein kinase of unknown function.
   
• YJR059W Putative serine/threonine protein kinase of unknown function.
   
• YJR061W Putative serine/threonine protein kinase of unknown function.
   
• YKL101W/YKL453 Serine/threonine protein kinase of unknown function, has probable purine-nucleotide binding domain.
   
• YKL116C/YKL516 Serine/threonine protein kinase with similarity to S pombe nim1.
   
• YKL161C/YKL615 Serine/threonine protein kinase of unknown function.
   
• YKL168C/YKL632 Serine/threonine protein kinase of unknown function.
   
• YKL171W/YKL635 Serine/threonine protein kinase of unknown function.
   
• YKL198C Serine/threonine protein kinase of unknown function.
   
• YM8261.03 Protein of unknown function, potential signal sequence at N-terminus.
   
• YM8261.10 Putative serine/threonine protein kinase, has similar to Cdc31p.
   
• YM9958.03 Protein kinase of unknown function.
  YNL020C/N2823 Serine/threonine protein kinase of unknown function.
   
• YNL161W/N1727 Putative serine/threonine protein kinase of unknown function.
   
• YNR047W/N3449 Serine/threonine protein kinase of unknown function.
   
• YPK1/YKL126W Serine/threonine protein kinase with similarity to protein kinase C with similarity to protein kinase C.
   
• YPK2/YKR2/YM9718.03 Serine/threonine protein kinase with similarity to Ypk1p.