Mammalian MAPK signalling pathways

Below is an image map of the main components of the signal transduction pathways that are structurally related to the mitogen-activated protein kinase pathway. Click on any of the objects to learn more about each gene product and the various interactions.

Agonists: [stresses] [mitogens] [neurotrophins] [inflammatory cytokines] [CD40]

The MAPK pathway: [receptor-tyrosine kinases] [Grb-2] [mSOS] [Ras] [Raf] [MEK] [MAPKs] [Rsk1]

The SAPK pathway: [Rac and Cdc42] [HPK] [GCK] [MLK3] [MEKK] [SEK] [SAPKs]

The p38 pathway: [PAK] [MEKK-X?] [MKK3 and 6] [p38] [MAPKAP kinase-2]

Targets: [Elk1] [c-Jun] [ATF-2] [HSP27]

Comments, ideas, data to add, etc, are very welcome.

Please email with suggestions.