Stress signal transduction pathways
studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein
Nutty Quiz
studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription We are studying the Stress-Activated Protein Kinase pathway (SAPK) which regulates several nuclear transcription factors and is activated by a wide variety of cellular stresses. Signalling components include SAPKs, SEK1, MEKK, MLK3, HPK and GC kinase. Targets include c-Jun and ATF2. Here is a clickable image map describing the components of the three known mammalian MAPK-related pathways.
Glycogen synthase kinase-3 biology
Study of glycogen synthase kinase-3 (GSK-3) continues to unearth surprises and we are actively investigating its function in diverse species using genetics, biochemistry and cell biology. Pages detailing the regulation, substrates and physiological functions of this kinase and its importance in insulin and Wnt signalling are in preparation. GSK-3 is specifically inhibited by lithium. Is this kinase a therapeutic target for bipolar disorders?
See the following recent publications for further details.
Nuclear Oncoproteins
In particular, post translational control of transcription factors that are also oncogenes such as c-Jun, c-Fos and c-Myc.
Protein kinases
A protein kinase resource web site devoted to protein kinases has recently been set up at the University of San Diego Supercomputing Centre. It's full of useful information. Here's a list of all the known budding yeast protein kinases extracted from the yeast genome database (with links to the genes). A comprehensive list of all protein kinases (720K) has also been compiled by the folks at the protein kinase resource (contains nearly 3,713 entries!).
Apoptosis
The stress-activated protein kinase pathways play many roles in cells including affecting cell viability in response to physical and chemical insult.
Support
Our laboratory is supported by research grants and fellowships from the CIHR, the Canadian Cancer Society/National Cancer Institute of Canada, the Terry Fox Foundation, and the Howard Hughes Medical Institute International Scholars Program
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