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Rac and Cdc42 are Rho-like GTPases and bind proteins such as the PAK kinases and the Wiscott-Aldrich Syndrome protein (WASP). Introduction of GTP clamped (active) forms of these proteins into cells causes activation of both the SAPK and p38 pathways via an as yet unknown mechanism. Transforming G proteins also induce SAPK
References
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