Publications

Current

Martinez AO, Yan NE, Tsai ELS, Comanita L, Gurdita A, Tachibana N, Liu ZC, Lu S, Dolati P, Pokrajac NT, El-Sehemy A, Nickerson PEB, Schuurmans C, Bremner R, Wallace V. Photoreceptor nanotubes mediate the in vivo exchange of intracellular material. EMBO J. Accepted.

Gurdita A; Nickerson PEB; Pokrajac NT; Ortín-Martínez A; Tsai ELS ; Comanita L; Yan NE; Dolati P; Tachibana N; Liu ZC; Pearson JD; Chen D; Bremner R; Wallace VA. InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes. 2021. iScience. In Press

Pearson JD, Huang K, Pacal M, McCurdy S, Lu S, Aubry A, Yu T, Wadosky KM, Zhang L, Wang T, Gregorieff A, Ahmad M, Dimaras H, Cole SPC, Monnier P, Lok BH, Tsao M, Akeno N, Wikenheiser-Brokamp KA, Knudsen ES, Witkiewicz AK, Wrana J, Goodrich DW, Bremner R. (2021) Alternate YAP/TEAD Enhancer Engagement Defines Pan‐Cancer Classes with Contrasting Vulnerabilities. Cancer Cell. In Press (Aug issue, Published online July 15^th).

Pearson JD, Trcka D, Hyduk SJ, Aynaud M-M, Hernández JJ, Peidis F, Lu S, Chan K, Mazzulli T, Attisano L, Pelletier L, Cybulsky MI, Wrana JL, Bremner R. Comparison of SARS-CoV-2 Indirect and Direct Detection Methods. 2021. Virol. J.  May 17;18(1):99. doi: 10.1186/s12985-021-01574-4. Earlier version on bioRxiv: https://www.biorxiv.org/content/10.1101/2020.05.12.092387v1

Aynaud MM, Hernandez JJ, Barutcu1S, Braunschweig U, Chan K, Pearson JD, Trcka D, Prosser SL, Kim J, Barrios-Rodiles M, Jen M, Song S, Shen J, Bruce C, Hazlett B, Poutanen S, Attisano L, Bremner R, Blencowe BJ, Mazzulli T, Han H, Pelletier L, Wrana JL. A Multiplexed, Next Generation Sequencing Platform for High-Throughput Detection of SARS-CoV-2.  2021. Nat Commun. 12:1405. doi: 10.1038/s41467-021-21653-y.

Amalfitano E, Karlikow M, Norouzi M, Jaenes K, Cicek S, Masum F, Mousavi PS, Guo Y, Tang L, Sydor A, Ma D, Pearson JD, Trcka D, Pinette M, Ambagala A, Babiuk S, Pickering B, Wrana J, Bremner R, Mazzulli M, Sinton D, Brumell JH, Green AA, Pardee K. A Glucose Meter Interface for Point-of-Care Gene Circuit-based Diagnostics. Nature Comm. 12:724.

Javed A, Mattar P, Lu S, Kruczek K, Kloc M, Gonzalez-Cordero A, Bremner R. Ali RR, Cayouette M. Pou2f1 and Pou2f2 cooperate to regulate the timing of cone photoreceptor production in the developing mouse retina. 2020.  Development. 147 (18): dev 188730.

Tsatskis Y*, Rosenfeld R* Pearson JD*, Boswell C*, Qu Y, Kim S, Fabian L, Mohammad A, Wang X, Robson MI, Krchma K, Wu J, Gonçalves J, Hodzic D, Wu S, Potter D, Pelletier L, Dunham WH, Anne-Claude Gingras, Sun Y, Meng J, Godt D, Schedl T, Ciruna B, Choi K, Perry J, Bremner R, Schirmer EC, Brill JA, Juriscova A and Helen McNeill.  *Equal contributions.  The NEMP family supports metazoan fertility and nuclear envelope stiffness. 2020. Science Advances. 6(35):eabb4591.

Aubry A, Pearson JD, Huang K, Livne-bar I, Ahmad M, Jagadeesan M, Khetan V, Ketela T, Brown KR, Yu T, Lu S, Wrana JL, Moffat J, Bremner R. Functional Genomics Identifies New Synergistic Therapies for Retinoblastoma. 2020. Oncogene. 39:5338-5355.

Lu Y, Shiau F, Yi W, Lu S, Wu Q, Pearson JD, Kallman A, Zhong S, Hoang T, Zuo Z, Zhao F, Zhang M, Tsai N, Zhuo Y, He S, Zhang J, Stein-O’Brien GL, Sherman TD, Duan X, Fertig EJ, Goff LA, Zack DJ, Handa JT, Xue T*, Bremner R*, Blackshaw S*, Wang X*, Clark BS*. Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development. 2020. Dev. Cell.18;53:473-91. *Cosenior authors.

Charish J, Shabanzadeh A, Chen D, Mehlen P, Sethuramanujam S, Harada H, Bonilha VL, Awatramani G, Bremner R, Monnier P.P. Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration. 2020. J Clin Invest. 2020 Apr 1;130(4):2054-2068. doi: 10.1172/JCI125898.

Aubry A, Yu T, Bremner R. Preclinical Studies Reveal MLN4924 is a Promising New Retinoblastoma Therapy. 2020. Cell Death Discovery. 6, 2. https://doi.org/10.1038/s41420-020-0237-8

Wei R, Ren X, Kong H, Lv Z, Chen Y, Tang Y, Wang Y, Xiao L, Yu, T, Hacibekiroglu S, Xiao L, Liang C, Nagy A, Bremner R*, Chen D*. Combined deletion of Vhl, Rb and p107 causes retinal angiomatous proliferation and retinal hemangioblastoma in mice. 2019. JCI Insight. 14;4(22). pii: 127889. doi: 10.1172/jci.insight.127889. * Cosenior authors.

Harada H, Farhani N, Wang XF, Sugita S, Charish J, Attisano L, Moran M, Cloutier JF, Reber M, Bremner R, Monnier PP. Extracellular phosphorylation drives the formation of neuronal circuitry. 2019. Nature Chem. Biol. 15:1035-1042

Zhang H, Bagherie-Lachidan M, Enderle L, Peidis F, Bremner R, Jain S, McNeill H. FAT4 fine-tunes kidney development by regulating RET signaling. 2019. Developmental Cell 48:780-792.

Abou El Hassan M, Huang K, Xu Z, Yu T, Bremner R. Frequent IRF1 Binding at Remote Elements without Histone Modification. 2018.  J. Biol. Chem. 293:10353-10362.

Zhou Y, Wei R, Zhang L, Chen Y, Liang C, Wang Y, Xiao L, Zhang J, Bremner R^*, and Chen D*. Rb is Required for Retinal Angiogenesis and Lamination. 2018. Cell Death and Disease. 9(3):370. doi: 10.1038/s41419-018-0411-6. *Cosenior authors.

Abou El Hassan M, Huang K, Eswara MBK, Xu Z, Yu T, Aubry A, Ni Z, Livne-bar I, Sangwan M, Ahmad M, and Bremner R. Properties of STAT1 and IRF1 Enhancers and the Influence of SNPs. 2017.  BMC Molecular Biology. 18:6.

Kirkham CL, Aguilar OA, Yu T, Tanaka M, Mesci A, Chu K-L, Fine JH, Mossman KL, Bremner R, Allan DSJ, Carlyle JR. Interferon-dependent induction of Clr-b during MCMV infection protects bystander cells from NK cells via NKR-P1B-mediated inhibition. 2017. Journal of Innate Immunity. 9(4):343-358. doi: 10.1159/000454926.

McCurdy S, Pacal M, Ahmad M, Bremner R. A CDK2 Activity Signature Predicts Outcome in CDK2-Low Cancers. 2016. Oncogene. PDF

2011-2015

Talaei N, Yu T, Manion K, Bremner R, Wither JE. Identification of the SLAM adapter molecule EAT-2 as a Lupus susceptibility gene that acts through impaired negative regulation of dendritic cell signaling. 2015. J. Immunol. 195(10):4623-31.

Abou El Hassan M, Huang K, Eswara MBK, Zhao M, Song L, Yu T, Liu Y, Liu JC, McCurdy S, Ma A, Wither J, Jin J, Zacksenhaus E, Wrana JL, Bremner R. Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways. 2015. PLoS One 10(6):e0126466. PDF

Abou El Hassan M, Yu T, Song L, Bremner R. Polycomb Repressive Complex 2 Confers BRG1-Dependency on the CIITA locus. 2015 J Immunology, 194(10):5007-13. PDF

Aubry A, Galiacy S, Ceccato L, Marchand C, Tricoire C, Lopez F, Bremner R, Racaud-Sultan C, Monsarrat B, Malecaze F, Allouche M. Peptides derived from the dependence receptor ALK are proapoptotic for ALK-positive tumors. 2015 Cell Death and Disease..6:e1736. PDF

Bremner R, Sage J.  The origin of human retinoblastoma.  2014 Nature. 514(7522):312-3. PDF

Tassew NG, Mothe A, Sabanzahdeh PA, Banerjee P, KoeberlPD, Bremner R, Tator CH, Monnier PM. Modifying lipid rafts promotes regeneration and functional recovery. 2014 Cell Reports. 8:1146-59. PDF

Pacal M, Bremner R. Induction of the ganglion cell differentiation program in human retinal progenitors prior to cell cycle exit. 2014 Developmental Dynamics. 243:712-29. PDF

Leung TK, Abou El Hassan M, Bremner R. A Rapid and Efficient Method to Purify Proteins at Replication Forks under Native Conditions. 2013 Biotechniques. 55(4):204-206. PDF
      Highlighted in an Editorial Comment
      Selected by Editors as one of top three Protein Papers in journal for 2013
      Highlighted as a key reference in Nature Rev Mol Cell Biol. 2014 15:340-56

Chen D, Chen Y, Forrest D, Bremner R.  E2f2 Induces Cone Photoreceptor Apoptosis Independent of E2f1 and E2f3. 2013. Cell Death and Differentiation. 20(7):931-940. PDF

Zencak D, Chen D, Schouwey K, Ekström P, Tanger E, Bremner R, van Lohuizen M, Arsenijevic Y. Retinal degeneration depends on Bmi1 function and re-activation of cell cycle proteins. 2013 Proc Nat Acad Sci. 110(7):E593-601. PDF

Cockburn D, Charish J, Tassew N, Eubanks J, Bremner R, Macchi P, and Monnier P. The double-stranded RNA-binding protein Staufen 2 regulates eye size. 2012 Mol. Cell. Neurosci. 51:101-11. 
      Featured on the cover.

Pacal M, Bremner R. Mapping differentiation kinetics in the mouse retina reveals an extensive period of cell cycle protein expression in post-mitotic newborn neurons. 2012 Developmental Dynamics. 10:1525-44. PDF

     Highlighted in an Editorial Comment.

Sangwan M, McCurdy SR, Livne-bar I, Ahmad M, Wrana JL, Chen D, and Bremner R.  Established and New Mouse Models Reveal E2f1 and Cdk2 Dependency of Retinoblastoma and Expose Strategies to Block Tumor Initiation.  2012 Oncogene. 31(48):5019-28. PDF
      Highlighted by Faculty of 1000 http://f1000.com/13777956

Wu L, Lam S, Cao H, Guan R, Duan R, van der Kooy D, Bremner R, Molday RS and Hu J. Subretinal gene delivery using helper-dependent adenoviral vectors. 2011 Cell & Bioscience. 1:15. PDF

2006-2010

Fischer M, Huber G, Beck S, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Remé C, van de Pavert S, Wijnholds J, Pacal M, Bremner R, Seeliger M. Noninvasive, in vivo Assessment of Mouse Retinal Structure Using Optical Coherence Tomography. 2009 PLoS One. 4:e7507. PDF

Bremner R. Retinoblastoma: An Inside Job. 2009 Cell 137: 992-993. PDF

Couto JM, Livne-Bar I, Xu Z, Cate-Carter T, Nathaniel A, Anderson B, Tannok R, Kerr EN, Lovett MW, Humphries T, Bremner R, Barr CL. Association of Reading Disabilities to a Region Marked by Acetylated H3 Histones in KIAA0319. 2009 American Journal of Medical Genetics B.

Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, Bremner R. Division and apoptosis of E2f-deficient retinal progenitors. 2009 Nature 462, 925-929.

Chong JL, Wenzel PL, Saenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen H-Z, Ouseph M, Wang S-H, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM and Leone G. A Switch of E2F1-3 Function from Activators in Progenitor Cells to Repressors in Differentiating Cells. 2009 Nature 462(7275):930-4.

Abou El Hassan M, Bremner R. A rapid simple approach to quantify chromosome conformation capture. 2009 Nucleic Acids Research 1:14 doi:10.1093/nar/gkp028. PDF

Fujieda H, Bremner R, Alan J. Mears, Sasaki H. Retinoic acid receptor-related orphan receptor α regulates a subset of cone genes during mouse retinal development. 2009 J Neurochem. 108:91-101. PDF

Ni Z, Abou El Hassan M, Xu Z, Yu T, Bremner R. The chromatin-remodeling enzyme BRG1 coordinates CIITA induction through many interdependent distal enhancers. 2008 Nat Immunol. 9:785-93 PDF

This article was featured in News and Views in same issue: New dimensions of CIITA. PDF

Chen D, Opavsky R, Pacal M, Tanimoto N, Wenzel P, Seeliger MW, Leone G Bremner R. Rb-Mediated Neuronal Differentiation through Cell-Cycle-Independent Regulation of E2f3a. 2007 PLoS Biol. Jul;5(7). PDF

McClellan KA, Ruzhynsky VA, Douda DN, Vanderluit JL, Ferguson KL, Chen D,Bremner R, Park DS, Leone G, Slack RS. Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. 2007 Mol Cell Biol. Jul;27(13):4825-43. PDF

Ni Z, Bremner R. Brahma-related gene 1-dependent STAT3 recruitment at IL-6 inducible genes. 2007 J Immunol. 178(1):345-51.

Pacal M, Bremner R. Insights from animal models on the origins and progression of retinoblastoma. 2006 Curr Mol Med. 6(7):759-81.PDF

Yu C, Mazerolle CJ, Thurig S, Wang Y, Pacal M, Bremner R, Wallace V. Direct and indirect effects of hedgehog pathway activation in the mammalian retina. 2006 Mol. Cell. Neurosci 32:274-282. PDF

Livne-Bar I, Pacal M, Cheung MC, Hankin M, Trogadis J, Chen D, Dorval KM and Bremner R. Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina. 2006 Proc Natl Acad Sci 103: 498849933. PDF

Dorval KM, Bobechko BP, Fujieda H, Chen S, Zack DJ, Bremner R. CHX10 targets a subset of photoreceptor genes. 2006 J. Biol. Chem. 281: 744-751. PDF

2000-2005

Bremner R, Chen D, Livne-bar I, Agochiya M. Update on retinoblastoma. 2005 Retina, 25:950-1.PDF

Zuyao Ni, Elizabeth Karaskov, Tao Yu, Steve Callaghan, Sandy Der, David Park, Zhaodong Xu, Samantha Pattenden, Bremner R. Apical Role for BRG1 in Cytokine-Induced Promoter Assembly. 2005 Proc Natl Acad Sci USA Oct 102:14611-14616. PDF

Heisler LE, Torti D, Boutros PC, Watson J, Chan C, Winegarden N, Takahashi M, Yau P, Huang TH, Farnham P, Jurisica I, Woodgett JR, Bremner R, Penn L, Der SD. CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome. 2005 Nuc Acids Res 33:2952-29611.PDF

Dorval K, Bobechko B, Ahmad KF, Bremner R. Transcriptional activity of the paired-like homeodomain proteins Chx10 and Vsx1. 2005 J Biol Chem. PDF

Dyer MA, Bremner R. The search for the retinoblastoma cell of origin. 2005 Nature Reviews in Cancer Feb;5(2):91-101

Ni B, Lin Z, Zhou L, Wang L, Jia Z, Zhou W, DiCiommo DP, Zhao J, Bremner R , Wu Y. Induction of P815 tumor immunity by DNA-based recombinant SemlikiForest virus or replicon expressing the P1A gene. 2004 Cancer Detection and Prevention 28:418-42525.

Bremner R, Chen D, Pacal M, Livne-bar I, Agochiya M. The RB protein family in retinal development and retinoblastoma: new insights from new mouse models. 2004 Dev Neurosci. 2004;26(5-6):417-34.

DiCiommo DP, Duckett A, Burcescu I, Bremner R* and Gallie BL*. Retinoblastoma protein purification and transduction of retina and retinoblastoma cells using improved alphavirus vectors. Invest Ophthalmol 2004 Vis Sci. 2004 Sep;45(9):3320-9. * Co-senior authors. PDF

Chen D, Livne-bar I, Vanderluit J, Slack R, Agochiya M, Bremner R. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death resistant cell-of-origin in retinoblastoma. 2004 Cancer Cell Jun;5(6):539-551.PDF

Commentaries on this article were made at the time in Cancer Cell PDF, Nature Reviews Cancer PDF and the Journal of the National Cancer Institute PDF.

Popkin DL, Watson MA, Karaskov E, Dunn GP, Bremner R, Virgin HW 4th. Murine cytomegalovirus paralyzes macrophages by blocking IFN gamma-induced promoter assembly. 2003 Proc Natl Acad Sci USA Nov 25;100(24):14309-14. PDF

Pattenden S, Klose R, Karaskov E, Bremner R. Interferon-g-induced chromatin remodeling at the CIITA locus is BRG1-dependent. 2002 EMBO J. 21:1978-86. PDF

Héon E, Sahr H, Greenberg H, Rootman D, Vincent AL, Billingsley G, Priston P, Taylor C, Dorval D, Chow R, McInnes R, Heathcote G, Westall C, Sutphin J,, Semina E, Bremner R, Stone EM. VSX-1: a gene for posterior polymorphous dystrophy and keratoconus. an unsuspected relationship. 2002 Human Molecular Genetics 11:1029-36 PDF

Wu J, Trogadis J, Bremner R. Rod and cone degeneration in the rd mouse is p53-independent. 2001 Molecular Vision 7:101-106. PDF

DiCiommo D, Gallie BL, Bremner R. Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer. 2000 Semin Cancer Biol 10: 255-269. PDF

Park DS, Morris EJ, Bremner R, Keramaris E, Padmanabhan J, Rosenbaum M, Shelanski ML, Geller HM, Greene LA. Involvement of retinoblastoma family members and E2F/DP complexes in death of neurons evoked by DNA damage. 2000 J. Neurosci. 20: 3104-3114. PDF

1999 -

Zhu XP, Pattenden S, Bremner R. pRB is required for interferon-gamma-induction of the MHC class II A-beta gene. 1999 Oncogene 18: 4940-4947. PDF

Diciommo D, Bremner R. Rapid, high level protein production using DNA-based Semliki Forest virus vectors. 1998 J. Biol. Chem. 273: 18060-18066. PDF

Bremner R, Du DC, Connolly M, Bridge P Ahmad KF, Mostachfi H, Rushlow D, Dunn JM, Gallie, BL. Deletion of RB exons 24 and 25 causes low penetrance retinoblastoma. 1997 Amer. J. Human Genet. 61: 556-570.